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Visar resultat 1 - 5 av 8 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Inflammatory Markers, Respiratory Diseases, Lung Function and Associated Gender Differences

    Författare :Inga Sif Ólafsdóttir; Christer Janson; Anders Blomberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; C-reactive protein; matrix metalloproteinase-9; tissue inhibitor of metalloproteinase-1; COPD; FEV1; FVC; lung function; systemic inflammation; gender differences; Lungmedicin; Lung Medicine;

    Sammanfattning : Systemic inflammation is associated with impaired lung function. Inflammation is part of asthma and chronic obstructive pulmonary disease (COPD), but the local and systemic inflammatory pattern differs. LÄS MER

  3. 2. Rectal Cancer - Tumor Biology and Prognostic Markers

    Författare :Eva Fernebro; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prognostic markers; Cytology; oncology; cancerology; Cytologi; onkologi; cancer; immunohistochemistry IHC ; chromosomal instability CIN ; microsatellite instability MSI ; tissue microarray TMA ; tissue inhibitor of metalloproteinase 1 TIMP-1 ; Rectal cancer; soluble urokinase plasminogen activator receptor suPAR ;

    Sammanfattning : Colorectal cancer is one of our most common malignancies and the second leading cause of cancer death worldwide. About 1/3 of the tumors are located in the rectum. LÄS MER

  4. 3. Importance of Hyaluronan-CD44 Signaling in Tumor Progression : Crosstalk with TGFβ and PDGF-BB Signaling

    Författare :Helena Porsch; Paraskevi Heldin; Véronique Orian-Rousseau; Uppsala universitet; []
    Nyckelord :extracellular matrix; growth factor; hyaluronan synthase; hyaluronidase; epithelial-mesenchymal transition; Molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : In order for solid tumors to metastasize, tumor cells must acquire the ability to invade the surrounding tissue and intravasate into blood- or lymph vessels, survive in the circulation and then extravasate at a distant site to form a new tumor. Overexpression of the glycosaminoglycan hyaluronan, and its adhesion receptor CD44, correlate with breast cancer progression. LÄS MER

  5. 4. Cervical ripening : an inflammatory process involving cytokines, metalloproteinases and foetal fibronectin

    Författare :Maria Sennström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :cervical ripening; interleukin-8; interleukin-6; granulocyte colony stimulating factor; metalloproteinase- 1; -3 - and -8; foetal fibronectin;

    Sammanfattning : The aim of the thesis was to identify cytokines, metalloproteinases and foetal fibronectin in human cervical tissue and to investigate if changes are of importance for the final cervical ripening. The human cervical ripening is a prerequisite for a normal start and progress of labour. LÄS MER

  7. 5. Systemic sclerosis : vascular, pulmonary and immunological aspects

    Författare :Grethe Neumann Andersen; Solbritt Rantapää Dahlqvist; Lucia Mincheva-Nilsson; Sören Jacobsen; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systemic sclerosis; interstitial lung disease; MMP-9; Th1 Th2; transcription factors; NO; iNOS; E-selectin; endothelium-dependent dilation; endothelium-independent dilation.; Rheumatology; Reumatologi;

    Sammanfattning : In systemic sclerosis (SSc), interstitial lung disease (ILD) and engagement of the vascular system lead to increased morbidity and mortality. The aim of this thesis was to elucidate, in a consecutively included cohort of SSc (limited and diffuse) patients (n = 33), the T cell cytokine profile driving the disease in ILD and to explore the role of matrix metalloproteinase 9 (MMP-9) and its inhibitor: tissue inhibitor of metalloproteinase 1 (TIMP-1) in the extracellular matrix (ECM) degrading process leading to fibrous scarring and honey combing. LÄS MER