Sökning: "tissue dissociation"

Visar resultat 11 - 15 av 20 avhandlingar innehållade orden tissue dissociation.

  1. 11. In vivo quantification of extrastriatal dopamine D2 receptors in the human brain

    Författare :Hans Olsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :FLB 457; positron emission tomography; pituitary; receptor density; affinity; benzamide; Scatchard; saturation; receptor occupancy;

    Sammanfattning : The dopamine D2 receptor subtype attracts considerable attention in research on the patophysiology and drug treatment of several neuropsychiatric disorders, such as schizophrenia and Parkinson's disease. The brain imaging technology Positron Emission Tomography (PET) has since long allowed for reliable quantification of the high density of dopamine D2 receptors in large brain structures such as the neostriatum. LÄS MER

  3. 12. Post-translational modifications of myelin oligodendrocyte glycoprotein in CNS autoimmunity

    Författare :Andreas Warnecke; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Autoimmunity towards components of the central nervous system (CNS) is a driving factor of nerve demyelination in Multiple Sclerosis (MS). The etiology of autoimmunity in MS pathogenesis remains elusive, but a combination of genetic predisposition and environmental triggers is theorized to initiate this complex disease. LÄS MER

  4. 13. Lipoprotein lipase-unstable on purpose?

    Författare :Liyan Zhang; Gunilla Olivecrona; Cecilia Holm; Umeå universitet; []
    Nyckelord :Biochemistry; Lipoprotein lipase; Apolipoprotein CII; dimerization; monomerization; Molecular chaperones; Biokemi;

    Sammanfattning : Lipoprotein lipase (LPL) is a central enzyme in lipid metabolism. It is a non-covalent, homodimeric and N-glycosylated protein, which is regulated in a tissue-specific manner and is dependent on an activator protein, apolipoprotein CII. Dissociation of active LPL dimers to monomers leads to loss of activity. LÄS MER

  5. 14. Deconvolution of Spatial Gene Expression in Cancer

    Författare :Linnea Stenbeck; Stefania Giacomello; Joakim Lundeberg; Vicent Pelechano; KTH; []
    Nyckelord :Spatial transcriptomics; Gene expression; Cancer; Bioteknologi; Biotechnology;

    Sammanfattning : Cancer is the second leading cause of death in the world, claiming nearly 10 million lives in 2020 alone. One of the main issues in anti-cancer treatment is the heterogeneity of the tumor microenvironment (TME). The TME consists of different cells that are critical for cancer development. LÄS MER

  7. 15. Strategies to improve cancer radioimmunotargeting

    Författare :Anders Ullén; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; : cancer; monoclonal antibody; antiidiotypic antibody; radioimmunotargeting; placental alkaline phosphatase; cytokeratin; BIAcore.;

    Sammanfattning : Radioimmunotherapy (RIT) and radioimmunolocalisation (RIL) are developing and promising technologies to diagnose and treat tumours by use of radiolabelled antibodies targeting tumour specific antigens. The major reason why RIL and RIT not are efficient enough, is the comparatively low accumulation of radiolabelled antibodies in the tumours. LÄS MER