Sökning: "time-of-flight secondary ion mass spectrometry"

Visar resultat 1 - 5 av 37 avhandlingar innehållade orden time-of-flight secondary ion mass spectrometry.

1. 1. Imaging of lipids and proteins in Alzheimer's disease using Time-of-Flight Secondary Ion Mass Spectrometry

   Författare :Louise M Carlred; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; QCM-D; fluorescence microscopy; ToF-SIMS; Amyloid-β; immunohistochemistry; Sulfatides; antibodies; liposomes; Alzheimer’s disease; Cholesterol;

   Sammanfattning : Alzheimer’s disease (AD) is a neurodegenerative disease characterized by the formation of senile plaques. These plaques, which consist of aggregations of a peptide called amyloid-β, are deposited in-between the nerve cells in the brain, where they disrupt the signaling processes. LÄS MER

3. 2. Molecular and epidemiological studies on eyes with pseudoexfoliation syndrome

   Författare :Amelie Botling Taube; Jonas Bergquist; Albert Alm; Eva Larsson; Hannu Uusitalo; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pseduoexfoliation syndrome; PEX; aqueous humor; cataract; cataract surgery; lens capsule; proteomics; mass spectrometry; MS; MALDI TOF MS MS; quantitative proteomics; iTRAQ; dimethyl labeling; imaging mass spectrometry; IMS; time of flight secondary ion mass spectrometry; TOF-SIMS; crystallin; epidemiology; risk factor; Ophtalmology; Oftalmiatrik;

   Sammanfattning : Pseudoexfoliation (PEX) syndrome is an age-related condition characterized by the production and accumulation of extracellular fibrillary material in the anterior segment of the eye. PEX predisposes for several pathological conditions, such as glaucoma and complications during and after cataract surgery. LÄS MER

4. 3. Development and Evaluation of Preparation Methods for the Analysis of Cell Membranes Using Time-of-Flight Secondary Ion Mass Spectrometry

   Författare :Jakob Malm; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; salt; cryofixation; TOF-SIMS; supported phospholipid bilayer; freeze drying; vacuum; cells; POPC; glutaraldehyde;

   Sammanfattning : The aim of this work was to evaluate and develop methods for preparing dry samples for TOF-SIMS analysis of cell membranes. For correct interpretation of the analysis data, an understanding of the effects that the preparation method has on the morphology and chemical structure of the sample must first be obtained. LÄS MER

5. 4. Development and Application of ToF-SIMS for Clinical and Microbiological Analysis

   Författare :Kelly Dimovska Nilsson; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ToF-SIMS; Imaging mass spectrometry; Antibiotic resistance; Basal cell carcinoma; Gas cluster ion beam; GCIB; Time-of-flight secondary ion mass spectrometry; BCC; Escherichia coli; E. coli; FabF; DapF; Lpp; Lipid A; ECAcyc; Depth profile;

   Sammanfattning : The aim of the work of this thesis was to further the implementation of timeof-flight secondary ion mass spectrometry (ToF-SIMS) in biological analysis and to generate new knowledge from the samples analysed. ToF-SIMS is a chemical analysis technique. LÄS MER

7. 5. Mass spectrometry of biopolymers based on ion-induced desorption

   Författare :Roman Alexandrovich Zubarev; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radiation sciences; Strålningsvetenskap; Radiation biology; Strålningsbiologi; Ion Physics; jonfysik;

   Sammanfattning : Various aspects of biopolymer molecular characterization by their molecular masses havebeen studied, with emphasis on ion-induced desorption and time-of-flight mass Spectrometry(TOF MS). Limitations of the average-isotopic mass concept, as well as the utility ofaccurate monoisotopic mass measurements for deriving amino-acid and elementalcompositions, are discussed. LÄS MER