Sökning: "tight junctions"
Visar resultat 21 - 25 av 44 avhandlingar innehållade orden tight junctions.
21. Studies of experimental brain trauma and ischemia : effects of Epo
Sammanfattning : Traumatic brain injury has attained a lot of scientific and clinical focus during a considerable amount of time but is still as of today regarded a highly lethal condition with a high degree of morbidity amongst the surviving. The complexity of the pathophysiological processes that start immediately after the primary injury are challenging – disruption of the blood-brain barrier (BBB), imbalance in metabolic supply and demand, neuroinflammation and formation of brain edema are some of the components in a plethora of existing processes. LÄS MER
22. Experimental and Clinical Necrotizing Enterocolitis
Sammanfattning : Necrotizing enterocolitis (NEC), a severe inflammatory disorder of the gastrointestinal tract with high morbidity and mortality, affects primarily preterm infants. The diagnosis represents a challenging task, and no biomarker has been found to aid early diagnosis with high accuracy. LÄS MER
23. Wnt signaling in early brain development and disease
Sammanfattning : Wnt/Planar Cell Polarity (PCP) signaling is involved in many cellular processes throughout the development of the embryo. These include control of proliferation, differentiation, migration and cell fate decisions. Deregulation of Wnt/PCP signaling can lead to many developmental abnormalities and cancer. LÄS MER
24. RhoGTPase Signaling in Cell Polarity and Gene Regulation
Sammanfattning : RhoGTPases are proteins working as molecular switches as they bind and hydrolyze GTP. They are in their active conformation when GTP is bound and are then able to interact with their effector proteins, which relay the downstream signaling. When the GTP is hydrolyzed to GDP, the RhoGTPase is inactivated. LÄS MER
25. Induction of epithelial-mesenchymal transition (EMT) in women's cancer : protective role of differentiation factors
Sammanfattning : Metastatic spread of cancer cells to vital organs is the predominant cause of death among women suffering from breast and ovarian cancer, and invasive cancer cells are in many cases resilient to standard drugs used in the clinic. Consequently, further understanding of the metastatic process and development of new strategies to target invasive cancer cells are needed. LÄS MER