Sökning: "thyroiditis"

Visar resultat 16 - 20 av 20 avhandlingar innehållade ordet thyroiditis.

1. 16. Genetic Studies of Immunological Diseases in Dogs and Humans

   Författare :Matteo Bianchi; Gerli Rosengren Pielberg; Marta Alarcón-Riquelme; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; complex disease; immunogenetics; autoimmunity; GWAS; NGS; canine model; dog; hypothyroidism; Addison s disease; IFNA; BACH2; Medical Genetics; Medicinsk genetik;

   Sammanfattning : This thesis presents genetic studies aiming at enlarging our knowledge regarding the genetic factors underlying two immune-mediated diseases, hypothyroidism and autoimmune Addison’s disease (AAD), in dogs and humans, respectively.Genetic and environmental factors are indicated to contribute to canine hypothyroidism, which can be considered a model for human Hashimoto’s thyroiditis (HT). LÄS MER

3. 17. Pathogenesis of arthritis in rats : genetic factors and inducing molecules

   Författare :Johnny C Lorentzen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :arthritis; adjuvants; autoimmunity; MHC; genetics; rat; cytokines;

   Sammanfattning : Rheumatoid Arthritis (RA) is a chronic joint disease for which there is presently no cure, possibly because rational design of therapy is hindered by lack of knowledge of disease mechanisms (pathogenesis), and disease causing genetic and inducing factors (etiology). In this thesis, etiopathogenetic clues were sought in experimental arthritis, induced in different rat strains using both specific and nonspecific triggers of the immune system, i. LÄS MER

4. 18. Mapping genetic diseases in northern Sweden

   Författare :Elisabet Einarsdottir; Dan Holmberg; Gösta Holmgren; Ulf Gyllensten; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; isolated populations; linkage disequilibrium; linkage analysis; genome-wide scan; hereditary sensory and autonomic neuropathy; type 1 diabetes mellitus; type 2 diabetes mellitus; autoimmune thyroid disease; Genetik; Clinical genetics; Klinisk genetik; medicinsk genetik; Medical Genetics;

   Sammanfattning : The population of northern Sweden has previously been shown to be well suited for the mapping of monogenic diseases. In this thesis we have tested the hypothesis that this population could also be used for efficient identification of risk genes for common diseases. LÄS MER

5. 19. Molecular aspects of post-Chornobyl and sporadic papillary thyroid carcinoma

   Författare :Andrii Dinets; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :papillary thyroid carcinoma;

   Sammanfattning : Papillary thyroid carcinoma (PTC) exhibits various molecular abnormalities, both when sporadic and radiation-related. PTC is still diagnosed in adult individuals who were younger than 18 years at the time of the Chornobyl accident in 1986 and lived within the contaminated area. LÄS MER

7. 20. Affective disorders and their treatments : implications for thyroid function

   Författare :Ingrid Lieber; Ursula Werneke; Michael Ott; Mats Eliasson; John McGrath; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bipolar disorder; affective disorder; lithium; thyroid dysfunction; hyperthyroidism; hypothyroidism; Delphi-consensus; psykiatri; Psychiatry;

   Sammanfattning : BackgroundThe relationship between affective disorders, mood-stabilisers and thyroid dysfunction is complex and poorly understood. Symptoms of thyroid dysfunction can overlap with symptoms of affective disorder, destabilise mood, and impact physical health. LÄS MER