Sökning: "thymidine"

Visar resultat 21 - 25 av 93 avhandlingar innehållade ordet thymidine.

  1. 21. Studies of autologous diced costal cartilage transplant : with special regard to the glycosaminoglycans after intramuscular implantation, and to 35S-sulphate and 3H-thymidine incorporation after intramucular implantation and further transplantation to the hip joint

    Författare :Rudolf Lemperg; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  3. 22. Cloning and characterization of human deoxyribonucleoside kinases : phosphorylation of anti-cancer and anti-viral nucleoside analogs

    Författare :Magnus Johansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :deoxyribonucleoside kinase; nucleoside analog; deoxycytidinekinase; deoxyguanosine kinase; thymidine kinase 1; thymidine kinase 2; deoxyribonucleosidephosphorylation; deoxyribonucleotides; anticancer therapy; antiviral therapy;

    Sammanfattning : Deoxyribonucleoside kinases catalyze the phosphorylation of deoxyribonucleosides to deoxyribonucleoside monophosphates. There are four major deoxyribonucleoside kinasesin human cells: thymidine kinase 1 (TKl), deoxycytidine kinase (dCK), deoxyguanosinekinase (dGK), and thymidine kinase 2 (TK2). LÄS MER

  4. 23. Optimization of suicide gene therapy in stem cell transplantation with special reference to the selection marker OuaSelect

    Författare :Alexandra Treschow; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Gene therapy; cell selection; suicide gene; cancer; immunotherapy; viral vectors; thymidine kinase; Na ; K -ATPase;

    Sammanfattning : For many patients suffering from leukemia and other hematological malignancies, allogeneic hematopoietic stem cell transplantation (HSCT) represents the only curative approach. However, an optimal HSCT procedure is yet to be developed. Transplant-related morbidity and mortality are severe complications arising from this treatment modality. LÄS MER

  5. 24. Quantitative cellular methods in the evaluation of prostate cancer

    Författare :Naining Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :prostate cancer; histopathology; nuclear morphology; DNA ploidy; S-phase fraction; thymidine kinas; Ki-67; cell proliferation; fluorescence cytometry; tissue PSA; prognosis;

    Sammanfattning : The distinction between those prostate cancers rapidly progressing and leading to death and those with little likelihood of causing death in cancer is a major goal in current prostate cancer research. Morphological tumor characteristics at present are the basis for evaluation of the prognosis of the disease. LÄS MER

  7. 25. Neurorestorative strategies involving neurogenesis, neuronal precursors and stem cells in animal models of Parkinson's disease

    Författare :Ming Zhao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Parkinson s disease; substantia nigra pars compacta; adult neurogenesis; stereology; apoptosis; dopamine; tyrosine hydroxylase; nestin; 5-bromodeoxyuridine; [3H]-thymidine; MPTP; 6-OHDA; platelet-derived growth factor-BB;

    Sammanfattning : The general aims of the thesis is to provide evidence for neurogenesis in the adult substantia nigra pars compacta (SNpc), where the dopamine-producing neurons lost in Parkinson's disease (PD) reside; to optimize methods used for detecting newborn nerve cells in adult brain regions with a low rate of neurogenesis; to explore the mechanism of nerve cell death in animal models of parkinsonism and early degenerative and restorative changes in nigral cell populations; and to develop a therapeutic approach that could translate into a future restorative disease-modifying strategy in PD. Paper I. LÄS MER