Sökning: "thromboxane A2"

Visar resultat 1 - 5 av 14 avhandlingar innehållade orden thromboxane A2.

1. 1. Conctraction-mediating receptors in human peripheral vessels with special reference to veins and lymphatics

   Författare :Trygve Sjöberg; Thoraxkirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Human; arteries; veins; lymphatis; contraction; in vitro; in vivo; adrenergic receptors; noradrenaline; cirazoline; phenylephrine; clonidine; calcium antagonists; nifedipine; diltiazem; prostaglandins; thromboxane A2; U-46619; BM-13.505; indomethacin;

   Sammanfattning : By means of a myograph, postjunctional alpha-adrenoceptors were characterized in human superficial epigastric arteries and veins obtained from health subjects. The rank order of potency of subtype selective agonists could not be used for receptor characterization in these vessels, whereas antagonists gave distinct results. LÄS MER

3. 2. Functional characterisation of receptors for cysteinyl leukotrienes in smooth muscle

   Författare :Eva Wikström Jonsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :cysteinyl leukotrienes; leukotriene receptor; histamine; antigen; smooth muscle; lipoxin; thromboxane; Schultz-Dale reaction;

   Sammanfattning : The cysteinyl leukotrienes (leukotriene C4, D4 and E4) have potent biological actions which significantly contribute to the airway obstruction in asthma. Several of these effects are blocked by drugs known as CysLT1-receptor antagonists, which have been introduced as new treatment for asthma. LÄS MER

4. 3. Studies on antibodies against phospholipids

   Författare :Leopold Årfors; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Antiphospholipid syndrome; anticardiolipin antibodies; lupus anticoagulants; platelets; platelet activation; complement activation; endothelial cells; thromboxane; prostacyclin; acetylsalicylic acid.;

   Sammanfattning : The main clinical features of the antiphospholipid syndrome (APLS) are arterial and venous thrombosis, repeated spontaneous abortions and thrombocytopenia. Diagnosed concomitant with an underlying disease the designation is secondary APLS; otherwise primary APLS. LÄS MER

5. 4. Structure and expression of the TP and EP1 prostanoid receptor genes

   Författare :Björn Båtshake; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsykologi; Neurologi; neurofysiologi; Neurology; neuropsychology; neurophysiology;

   Sammanfattning : Prostanoids are ubiquitously distributed lipid signaling molecules derived from arachidonic acid, that exhibit numerous and diverse biological effects in a variety of physiological and pathophysiological conditions. The cell surface receptors for the prostanoids belong to the family of G protein-coupled receptors. LÄS MER

7. 5. Methodological studies of eicosanoid enzyme gene expression in vascular endothelium exposed to biomechanical stress

   Författare :Roya Doroudi; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prostanoids; endothelium; quantitative RT-PCR; perfusion model; shear stress; intraluminal pressure; immediate-early genes;

   Sammanfattning : Prostaglandins are the major eicosanoids synthesized by vascular endothelial cells, and the vasculature is an important target organ for their bioactive metabolites. In vitro studies have shown that biomechanical forces are important regulators of vascular expression of prostanoid enzymes and release of metabolites. LÄS MER