Sökning: "thrombomodulin"

Visar resultat 11 - 15 av 17 avhandlingar innehållade ordet thrombomodulin.

  1. 11. Studies on the cultured human endothelial cell with special regard to clinical applicability

    Författare :Caroline Gillis-Hægerstrand; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The improvement of cardiovascular prosthetic materials, to reduce thrombus formation and inflammatory / immunological reactions, is a clinical challenge. Endothelial cell (EC) seeding using autologous cells to line the luminal surface of prosthetic materials has been suggested. LÄS MER

  3. 12. The effect of thrombin inhibitors on coagulation activity and generation of activated protein C

    Författare :Rikard Linder; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The direct thrombin inhibitor inogatran was, in the TRIM trial (n=1209), compared with unfractionated heparin (UFH) concerning the effect on cardiovascular end-points in unstable coronary artery disease. The results in TRIM demonstrated a trend towards a benefit for UFH during the treatment phase, which was reduced after drug withdrawal. LÄS MER

  4. 13. Risk markers for a first myocardial infarction

    Författare :Anna Margrethe Thøgersen; Annika Rosengren; Umeå universitet; []
    Nyckelord :haemostatis; lipoprotein a ; MTHFR; homocysteine; proinsulin; leptin; apolipoprotein A1; DHEAS; myocardial infarction; risk factors;

    Sammanfattning : The development of a first myocardial infarction is associated with a large number of contributing factors. Age, male sex, hypertension, smoking, diabetes, body mass index and hypercholesterolemia are considered as established risk factors. LÄS MER

  5. 14. Identification of genetic biomarkers for the risk prediction of recurrent venous thromboembolism. Risk prediction of recurrent VTE

    Författare :Abrar Ahmad; Allmänmedicin och klinisk epidemiologi; []
    Nyckelord :Recurrent venous thromboembolism; Genetic risk score; Multibiomarker;

    Sammanfattning : Background: Venous thromboembolism (VTE) is the third most frequent life-threatening cardiovascular disease with an annual incidence rate of 1-2 per 1000 person-years. After the diagnosis for primary VTE, about 20-30% patients develop a recurrence within 5-years. LÄS MER

  7. 15. Thrombin activatable fibrinolysis inhibitor (TAFI) in different hemorrhagic and thrombotic conditions

    Författare :Jovan P Antovic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Thrombin activatable fibrinolysis inhibitor TAFI ; coagulation; fibrinolysis; thrombin; plasmin; factor V Leiden; hemophilia; von Willebrand disease; diabetes mellitus; preeclampsia;

    Sammanfattning : Until recently the coagulation and fibrinolytic systems were usually considered as separate entities. Accounts of a fibrinolysis inhibitor that is generated by thrombin shed more light on this field and changed the concept by giving thrombin, the pivotal enzyme in hemostasis, another important role in the down-regulation of fibrinolysis. LÄS MER