Sökning: "thrombin generation"

Visar resultat 1 - 5 av 50 avhandlingar innehållade orden thrombin generation.

  1. 1. Thrombin generation in different cohorts : Evaluation of the haemostatic potential

    Författare :Roza Chaireti; Tomas Lindahl; Elvar Theodorsson; Sven Almer; Per Morten Sandset; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : The aim of this thesis is to evaluate thrombin generation in patients with thrombophilia (Paper I), in patients with venous thromboembolism (Paper II), in healthy women during the menstrual cycle (Paper III), in patients with liver disease (Paper IV) and in patients with mild deficiency of factor VII (Paper V).For this purpose, thrombin generation was measured in platelet poor plasma by the calibrated automated thrombogram (CAT®) assay. LÄS MER

  3. 2. Bleeding tendency and health-related quality of life in carriers of haemophilia

    Författare :Anna Olsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Carriers of haemophilia; Bleeding; SF-36; Thrombin generation; Genotype;

    Sammanfattning : Haemophilia A and B are X-linked disorders caused by impaired synthesis of coagulation factors VIII and IX, respectively. Women who carry the haemophilia trait have about 50 % of normal factor levels. LÄS MER

  4. 3. Novel Aspects of the Coagulation System in Host Defence

    Författare :Praveen Papareddy; Lund Dermatologi och venereologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Host defence peptides; Coagulation system; Sepsis; Thrombin; TFPI-1; TFPI-2; HCII;

    Sammanfattning : Bacterial infections are a major global threat to public health and sepsis is a major cause of morbidity and mortality. Sepsis incidence is rising, with supportive treatments and antibiotics being the main treatment possibilities. LÄS MER

  5. 4. Experimental studies on thrombosis and thrombolysis : With special reference to importance of lys-plasminogen, active site thrombin inhibitors and stable fish oil

    Författare :Liying Chen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Thrombolysis; thrombosis; recombinant tissue-type plasminogen activator; lys- and glu-plasminogen; aspirin; thrombin inhibitors; platelets; superoxide dismutase; stable fish oil; Kirurgi; Surgery; Kirurgi; rättsmedicin; Forensic Medicine;

    Sammanfattning : Dissolution and prevention of thrombus in the atherosclerotic coronary artery have become an important part of treatment therapy of acute myocardial infarction. However, the currently most effective thrombolytic agent, recombinant tissue-type plasminogen activator (rt-PA), only elicits 80% recanalization of thrombotically occluded coronary arteries and early occlusion occurs in about 40% of successfullyrecanalized vessels. LÄS MER

  7. 5. Platelet function and thrombin generation in ischemic stroke : clinical correlates and prognostic importance

    Författare :Annika Lundström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Platelet function is central to atherothombotic diseases and antiplatelet agents prevent non-cardioembolic ischemic stroke (IS). Individual differences in platelet reactivity may limit the response to antiplatelet treatment, leading to so-called high on-treatment platelet reactivity (HPR). LÄS MER