Sökning: "three-component reaction"
Visar resultat 1 - 5 av 16 avhandlingar innehållade orden three-component reaction.
1. The three-component aza-Baylis-Hillman reaction : development and application
Sammanfattning : The current thesis presents the optimization and generalization of the Baylis-Hillman reaction applied to in situ generated imines, i.e. a three-component aza- Baylis-Hillman reaction. We found that the title reaction proceeds most efficiently in the presence of a combination of catalysts, i. LÄS MER
2. Bifunctionalization of Small Organic Molecules Based on Fluorine Incorporation
Sammanfattning : The dissertation work that is summarized in this thesis describes novel syntheses of organofluorine compounds with a broad coverage of different fluorine-containing motifs.Chapter 2.1 covers works on the exploration of new trifluoromethylthiolating reactions of diazocarbonyl compounds. LÄS MER
3. Synthesis of indole and oxindole derivates incorporating pyrrolidino, pyrrolo or imidazolo moieties
Sammanfattning : The focus of this thesis is on the synthesis of oxindole- and indole-derivatives incorporating pyrrolidins, pyrroles or imidazoles moieties. Pyrrolidino-2-spiro-3'-oxindole derivatives have been prepared in high yielding three-component reactions between isatin, alpha-amino acid derivatives, and suitable dipolarophiles. LÄS MER
4. Synthesis of chiral allyl and propargyl boronates by organocatalytic carbene insertion to carbon-boron bonds
Sammanfattning : This thesis describes the development of a novel organocatalytic method for the synthesis of chiral allyl- and propargyl- organoboron compounds with high enantioselectivity. These organoboron species are versatile building blocks in asymmetric synthesis.We have developed a new efficient homologation method of alkenyl boronic acids. LÄS MER
5. New Methods for the Synthesis of 3-Substituted 1-Indanones : A Palladium-Catalyzed Approach
Sammanfattning : In medicinal chemistry, there is a constant need for new preparative methods, both to make the synthesis process more effective, and to increase the accessibility to a wide variety of compounds. A number of different approaches can be used to attain these goals. LÄS MER
