Sökning: "thomas tängden"

Hittade 4 avhandlingar innehållade orden thomas tängden.

  1. 1. Multidrug-Resistant Escherichia coli and Klebsiella pneumoniae : Treatment, Selection and International Spread

    Författare :Thomas Tängdén; Otto Cars; Anders Johansson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Escherichia coli; Klebsiella pneumoniae; extended-spectrum beta-lactamases; carbapenemases; metallo-beta-lactamases; synergy; antibiotic interventions;

    Sammanfattning : The prevalence of Escherichia coli and Klebsiella pneumoniae producing extended-spectrum beta-lactamases (ESBLs) and carbapenemases is increasing worldwide. Therapeutic options for infections with these bacteria are limited not only by the production of ESBLs and carbapenemases, which confer resistance to cephalosporins and carbapenems, but also by frequent co-resistance to other antibiotics. LÄS MER

  3. 2. β-lactam combinations against multidrug-resistant Enterobacterales : Exploring combination effects and resistance development

    Författare :Lisa Allander; Thomas Tängdén; Linus Sandegren; Pernilla Lagerbäck; Arnfinn Sundsfjord; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gram-negative bacteria; antibiotic combination therapy; antibiotic resistance; beta-lactams; beta-lactamase inhibitors; Infektionssjukdomar; Infectious Diseases;

    Sammanfattning : The β-lactam antibiotics are a cornerstone in treating bacterial infections, but the increasing prevalence of antibiotic resistance worldwide threatens their effectiveness. The main driver of β-lactam resistance is the production of β-lactamases, which are bacterial enzymes that inactivate the antibiotic. LÄS MER

  4. 3. Development of a robust and rapid microfluidics-based antibiotic susceptibility test : From prototype to clinical implementation

    Författare :Christer Malmberg; Johan Kreuger; Thomas Tängdén; Till Bachmann; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lab-on-a-chip; rapid antibiotic susceptibility testing; AST; sepsis; microfluidics; blood culture; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Even though bacteria normally are rapidly cleared from the blood by the immune system, a blood stream infection may arise, in turn possibly leading to sepsis and septic shock. Sepsis is a life-threatening condition, where the inflammatory response to infection targets tissues and organs. LÄS MER

  5. 4. Exploring the interactions of antibiotic combinations against multidrug-resistant Gram-negative bacteria

    Författare :Anna Olsson; Thomas Tängdén; Linus Sandegren; Pernilla Lagerbäck; Joseph Meletiadis; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gram-negative bacteria combination therapy antimicrobial resistence; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Antimicrobial resistance is emerging and available treatment options are lacking. Antibiotics is a cornerstone in modern medicine where medical procedures such as surgery, care of premature babies or treatment of cancer is dependent on efficient drugs. LÄS MER