Sökning: "therapeutics"

Visar resultat 21 - 25 av 217 avhandlingar innehållade ordet therapeutics.

  1. 21. Quantitative NanoSIMS provides subcellular concentration and distribution of oligonucleotide therapeutics

    Författare :Cécile Becquart; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NanoSIMS; Antisense Oligonucleotide; Intracellular concentration;

    Sammanfattning : Antisense oligonucleotides (ASOs) represent a powerful therapeutic modality that can selectively modulate gene expression. However, ASOs face two major hurdles that restrict their use in the clinic. The first issue is delivery of the ASO to a tissue of therapeutic interest while reducing exposure to unrelated tissues. LÄS MER

  3. 22. Potential New Drugs in Lymphoma

    Författare :Maryam Delforoush; Gunilla Enblad; Mattias Berglund; Christina Drott; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lymphoma; diffuse large B-cell lymphoma; DLBCL; picropodophyllin; PPP; J1; melflufen; prodrug; cancer therapeutics; alkylating agents; b-AP15; proteasome inhibitors; DUB inhibition; UCHL5; USP14;

    Sammanfattning : Lymphomas are malignant tumours arising from cells in the lymphatic system. They are classified as B-cell lymphomas, T-cell lymphomas and Hodgkin lymphoma (HL). Of the B-cell lymphomas, one of the most common is diffuse large B-cell lymphoma (DLBCL). LÄS MER

  4. 23. Development of therapeutics for the treatment of diabetic brain complications

    Författare :Shiva Mansouri; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Type-2 diabetes (T2D) is characterized by hyperglycemia and hyperlipidemia, resulting in impaired insulin production and insulin resistance in peripheral tissues. Several studies have demonstrated an association between diabetes and central nervous system complications such as stroke and Alzheimer’s disease. LÄS MER

  5. 24. Microcirculation in chronic kidney disease : from injury targets to potential therapeutics

    Författare :Samsul Arefin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chronic kidney disease (CKD) is a major public health problem worldwide, and patients with end-stage kidney disease (ESKD) are at increased risk of developing cardiovascular complications. Small artery dysfunction is a common feature of CKD, which contributes to the development of early vascular ageing (EVA) and cardiovascular complications. LÄS MER

  7. 25. Mitochondria-endoplasmic reticulum contacts in neuronal cells : from physiology to therapeutics

    Författare :Giacomo Dentoni; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mitochondria and the endoplasmic reticulum (ER) are intracellular organelles that play vital physiological functions. Mitochondria are key players in energy production through adenosine triphosphate (ATP) production and calcium (Ca2+) buffering, while the ER is involved in protein and lipid synthesis along with Ca2+ signalling in the cell. LÄS MER