Sökning: "therapeutics"

Visar resultat 16 - 20 av 217 avhandlingar innehållade ordet therapeutics.

  1. 16. Cerebral Mitochondrial Dysfunction and the Development of Targeted Therapeutics

    Författare :Michael Karlsson; Mitokondriell Medicin; []
    Nyckelord :mitochondria; brain; animal models; sepsis; traumatic brain injury; neuroprotection; cyclosporine;

    Sammanfattning : .... LÄS MER

  3. 17. Experimental Diagnostics and Therapeutics of Invasive Urinary Bladder Cancer

    Författare :Amir Sherif; Per-Uno Malmström; Magnus Thörn; Lars Holmberg; Sten Nilsson; Michael J Droller; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Bladder cancer; Cystectomy; Neoadjuvant chemotherapy; Kirurgi; Lymph node excision; Radionuclide imaging; Gene expression; Surgery; Kirurgi; kirurgi; särskilt urologi; Urology;

    Sammanfattning : The two purposes of this thesis were to evaluate new diagnostic techniques of lymphnode staging in invasive bladder cancer and to evaluate the results of neoadjuvant chemotherapy in invasive bladder cancer.Sentinel node detection was performed in 13 patients in preparation for radical cystectomy. LÄS MER

  4. 18. Design and application of RNA therapeutics for splice site mutations

    Författare :Burcu Bestas; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Precursor messenger RNA splicing is one of the most fundamental and complex mechanisms in eukaryotes. Over 90% of the human genes undergo alternative splicing, which is essential for the regulation of gene expression. A dynamic RNA-protein complex called the spliceosome catalyzes splicing. LÄS MER

  5. 19. Detection and quantification of lipid-mediated siRNA delivery to the cytosol

    Författare :Hampus Hedlund; Tumörmikromiljö; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; RNA Interference; RNA Therapeutics; Endosomal Escape; Lipid Mediated Delivery; Live-Cell Imaging;

    Sammanfattning : Cancer is one of the leading causes of death globally. Novel therapeutics is urgently needed to advance treatment, especially for generalized disease where current treatment options have a poor prognosis. In particular, targeted therapy that can address genetic changes would be of great value. LÄS MER

  7. 20. Design, expression, and analysis of antibody-based blood-brain barrier shuttles

    Författare :Andrés de la Rosa; Greta Hultqvist; Paul O'Callaghan; Nicole G. Metzendorf; Torben Moos; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antibody therapeutics; transient gene expression; protein production; blood-brain barri-er BBB ; BBB shuttle; brain delivery; Transferrin receptor TfR ; heparan sulfate; holo-transferrin; Molekylär biovetenskap; Molecular Life Sciences;

    Sammanfattning : Antibody therapeutics, with their strong and highly selective target binding, are now used to treat various diseases. However, to enable their use to treat brain disorders, they must be delivered across the blood-brain barrier (BBB), as without active transport, only around 0.01% of intravenously injected doses reach the brain. LÄS MER