Sökning: "therapeutics and cancer"

Visar resultat 1 - 5 av 60 avhandlingar innehållade orden therapeutics and cancer.

  1. 1. Quiescent cancer cells : Three-dimensional cell models for evaluation of new therapeutics

    Författare :Frida Ek; Mårten Fryknäs; Malin Jarvius; Rolf Larsson; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; cancer cell quiescence; dormancy; three-dimensional; multicellular tumor spheroids; model development; cancer pharmacology; mitochondria; OXPHOS; colorectal carcinoma; hepatocellular carcinoma; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Inadequate metabolic conditions in solid tumors lead to the formation of quiescent cancer cells that are suspended in a transient cell cycle arrest. When conditions change, quiescent cancer cells can re-enter the cell cycle and cause recurrence. LÄS MER

  2. 2. Immunohistochemical and molecular studies on ovarian cancer progression and prognosis

    Författare :Björn Nodin; Tumörmikromiljö; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epithelial ovarian cancer; prognostic and predictive biomarkers; tissue microarrays; androgen receptor; RBM3; Chek1; Chek2; MCM3; Dachshund 2; SATB1; KRAS mutation;

    Sammanfattning : Epithelial ovarian cancer (EOC) is the most lethal malignancy of the female reproductive tract. Due to vague symptomatology, the majority of EOC patients are diagnosed in advanced clinical stages with poor survival rates, despite improvements in surgical techniques and the advent of targeted therapeutics. LÄS MER

  3. 3. Biophysical aspects of the skin barrier : towards increased non-invasive extraction and optimized biomarker sampling

    Författare :Maxim Morin; Johan Engblom; Sebastian Björklund; Nicole K Brogden; Malmö universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : The skin provides a link to the body’s health via its rich variety of high and low molecular weight biomarkers, reflecting both systemic diseases (e.g., cancer, diabetes) and local skin disorders (e.g. LÄS MER

  4. 4. Potential immunoregulatory role of T and dendritic cells in cancer : Investigations based on transcriptional analysis

    Författare :Milad Abolhalaj; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; Dendritic cells; T cells; head and neck cancer; acute myeloid leukemia; bladder cancer; T cell exhaustion;

    Sammanfattning : Cancer is a complex disease with various genetic and epigenetic driving factors. Cancer cells form a favored microenvironment to sustain their uncontrolled behavior leading to abnormal growth. With standard treatment including chemotherapy, relapse risk is high due to the resistance that cancer cells can develop against chemotherapy agents. LÄS MER

  5. 5. From a Road Less Travelled to a Worn Path: Three-Dimensional Tumour Models for Cancer Research and Therapeutics

    Författare :Atena Malakpour Permlid; NanoLund: Center for Nanoscience; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; 3D tumour models; scaffold-based cultures; cancer cells; electrospun scaffolds; extracellular matrix; tumour microenvironment; high-throughput screening; animal-free; donor herd horse serum; fibroblasts;

    Sammanfattning : Cancer is the second leading cause of death among both men and women worldwide. During therecent years, three-dimensional (3D) tumour models have gained increasing interest as a pre-clinicalplatform for screening of compounds for potential use in cancer therapy. LÄS MER