Sökning: "therapeutic drug monitoring"
Visar resultat 16 - 20 av 66 avhandlingar innehållade orden therapeutic drug monitoring.
16. Inappropriate prescribing, non-adherence to long-term medications and related morbidities : Pharmacoepidemiological aspects
Sammanfattning : Background: Inappropriate use of medications (IUM), in particular inappropriate prescribing and non-adherence to prescribed medications, are important causes of drug-related morbidities (DRMs). They are increasing problems with the ageing populations and the growing burden of chronic conditions. LÄS MER
17. Metabolic drug interactions in man : methodological aspects on in vivo studies
Sammanfattning : The aim of this thesis was to investigate methodological aspects on in vivo metabolic drug interaction studies in man. Five pharmacokinetic studies in healthy persons or patients are presented. Together, they represent a set of model studies to evaluate the occurrence of, and extent of metabolic drug interactions in vivo. LÄS MER
18. Studies on warfarin treatment with emphasis on inter-individual variations and drug monitoring
Sammanfattning : Waran används sedan 60 år som blodförtunnande läkemedel för att förebygga eller förhindra progress av blodproppssjukdom. I Sverige behandlas årligen cirka 1 % av befolkningen med waran. I Östergötland uppskattas antal waranpatienter till cirka 3000. Waran hämmar enzymet VKORC1 som ansvarar för vitamin K omsättningen i kroppen. LÄS MER
19. From achiral to chiral analysis of citalopram
Sammanfattning : Within the field of depression the “monoamine hypothesis” has been the leading theory to explain the biological basis of depression. This theory proposes that the biological basis of depression is due to a deficiency in one or more of three key neurotransmitter systems, namely noradrenaline, dopamine and serotonin which are thought to mediate the therapeutic actions of virtually every known antidepressant agent. LÄS MER
20. A pharmacokinetic and pharmacodynamic study of an antiepileptic drug (lamotrigine) in young patients with drug-resistant generalized epilepsy
Sammanfattning : The purpose of the present study was to investigate the safety and efficacy of lamotrigine in young patients with drug-resistant generalised epilepsy. This group of patients is difficult to study due to a high seizure frequency, comorbidity and the frequent use of polytherapy. LÄS MER