Sökning: "the role of circulating biomarkers"

Visar resultat 1 - 5 av 39 avhandlingar innehållade orden the role of circulating biomarkers.

1. 1. Insulin Resistance : Causes, biomarkers and consequences

   Författare :Christoph Nowak; Tove Fall; Erik Ingelsson; Johan Sundström; Rachel Freathy; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; insulin resistance; diabetes; insulin secretion; cardiovascular; mendelian randomization; proteomics; metabolomics; genomics; molecular epidemiology; complex disease; risk prediction; coronary heart disease; stroke; hyperglycemia;

   Sammanfattning : The worldwide increasing number of persons affected by largely preventable diseases like diabetes demands better prevention and treatment. Insulin is required for effective utilisation of circulating nutrients. LÄS MER

3. 2. Circulating platelets : a novel liquid biopsy source for cancer diagnostics and therapy stratification

   Författare :Lee-Ann Tjon-Kon-Fat; Jonas Nilsson; Pernilla Wikström; Michiel Pegtel; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; platelets; biomarkers; liquid biopsy; therapy stratification; personalised medicine; Prostate cancer;

   Sammanfattning : As conventional tissue biopsies have several drawbacks, much effort has been directed toward the development of minimal-invasive liquid biopsy platforms for detecting and profiling cancer.Platelets are the second most abundant cells in blood and have very versatile functions both in physiological and pathophysiological conditions. LÄS MER

4. 3. Molecular Epidemiology of Cardiovascular Disease

   Författare :Markus Stenemo; Johan Ärnlöv; Rikard Landberg; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomarkers; ischemic stroke; heart failure; omics; proteomics; metabolomics; epidemiology; risk marker; Epidemiologi; Epidemiology;

   Sammanfattning : Cardiovascular disease is a major cause of morbidity and mortality, with increasing prevalence worldwide.Identification of risk markers may enable improved prevention by targeting high-risk individuals, earlier disease diagnosis and treatment, as well as stratification of disease subtypes with different treatment options, thereby minimizing side effects while increasing success rates. LÄS MER

5. 4. The role of circulating biomarkers, genetics, and diet in kidney function

   Författare :Christina-Alexandra Schulz; Diabetes - kardiovaskulär sjukdom; []
   Nyckelord :biomarker; Chronic kidney disease CKD ; Diet;

   Sammanfattning : Today, between 8% and 16% of all individuals worldwide suffer from chronic kidney disease (CKD), which is becoming a growing public health issue. Creatinine and cystatin C are commonly used markers for kidney function, and estimated glomerular filtration rate (eGFR) and albuminuria are used to stage CKD. LÄS MER

7. 5. Role of Fatty Acid Composition in Non-Alcoholic Fatty Liver Disease: a Dietary Perspective : Results from Interventional and Observational Studies

   Författare :Michael Fridén; Ulf Risérus; Fredrik Rosqvist; Helen Lindqvist; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fatty acids; Diet; Biomarkers; NAFLD; Liver fat; Fibrosis; Cirrhosis; HCC; Nutrition; Nutrition;

   Sammanfattning : The overall aim of this doctoral thesis was to investigate the role of circulating, liver and dietary fatty acids in non-alcoholic fatty liver disease (NAFLD). For circulating and liver fatty acids, special emphasis was given to fatty acids reflecting diet. LÄS MER