Sökning: "tetracyclines"

Visar resultat 1 - 5 av 10 avhandlingar innehållade ordet tetracyclines.

  1. 1. Towards surgical use of matrix metalloproteinase biology

    Författare :Björn Pasternak; Per Aspenberg; Pentti Tengvall; Yrjö T Konttinen; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Achilles tendon; colon; tetracyclines; tissue inhibitor of metalloproteinases TIMP ; wound healing.; colorectal surgery; extracellular matrix; humans; matrix metalloproteinases MMPs ; rats; surgical anastomosis; sutures; tendon injuries; Orthopaedics; Ortopedi;

    Sammanfattning : Matrix metalloproteinases (MMPs), such as collagenases, are a family of enzymes capable of degrading most constituents of the extracellular matrix. MMPs are thought to be involved in the aetiopathogenesis of tendon rupture. Additionally, failure of healing has in some instances been associated with elevated levels of MMPs. LÄS MER

  3. 2. In vitro studies on anti-leukemic effects of tetracycline's analogues and cyclophosphamide

    Författare :Mona Fares; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Leukemia is a heterogeneous group of hematological malignancies that originate from the bone marrow. Leukemias are classified as acute or chronic. Although acute leukemia affects patients of all ages, acute lymphoid leukemia is predominant in children and young adults while acute myeloid leukemia (AML) is predominant in the elderly. LÄS MER

  4. 3. Evolution and Mechanisms of Tigecycline Resistance in Escherichia coli

    Författare :Marius Linkevičius; Dan I. Andersson; Linus Sandegren; Patrice Courvalin; Uppsala universitet; []
    Nyckelord :Tigecycline; Bacterial resistance; Fitness; Escherichia coli; AcrAB; LPS; Tet proteins; Tet A ; Tet K ; Tet M ; Tet X ; tet genes; pUUH239.2; Mikrobiologi; Microbiology;

    Sammanfattning : Antibiotic resistance is an ongoing global medical crisis and we are in great need of new antibacterial agents to combat rapidly emerging resistant pathogens. Tigecycline is one of few drugs that have been introduced into medicine during the last two decades. LÄS MER

  5. 4. New antibiotic resistance genes and their diversity

    Författare :Fanny Berglund; Chalmers tekniska högskola; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; metagenomics; β-lactamases; hidden Markov model; antibiotic resistance; carbapenemases; big data; tetracycline resistance;

    Sammanfattning : Antibiotic resistance is increasing worldwide and is considered a severe threat to public health. Often, antibiotic resistance is caused by antibiotic resistance genes, of which many are hypothesized to have been transferred into human pathogens from environmental bacteria. LÄS MER

  7. 5. Fluoroquinolone resistance in the environment and the human gut – Analysis of bacterial DNA sequences to explore the underlying genetic mechanisms

    Författare :Anna Johnning; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antimicrobial resistance; Quinolones; Pollution; Next generation sequencing; Bioinformatics; Next generation sequencing;

    Sammanfattning : Fluoroquinolones (FQs) are synthetic, broad-spectrum antibiotics that target type II topoisomerases. High-level resistance is often caused by mutations in the target genes of FQs, especially in gyrA and parC. In contrast, plasmid-mediated resistance genes, such as qnr, often confer moderate levels of resistance. LÄS MER