Sökning: "test cell"

Visar resultat 1 - 5 av 632 avhandlingar innehållade orden test cell.

  1. 1. Development and application of a patient-derived xenograft platform to test anticancer agents

    Författare :Berglind Einarsdottir; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; malignant melanoma; patient-derived xenografts; MTH1; pre-clinical trial; Karonudib;

    Sammanfattning : Malignant melanoma is the most aggressive form of skin cancer and incidence rates are on the rise. Despite recent improvements in treatment options, the disease still remains lethal. Which calls for expedited solutions. LÄS MER

  3. 2. Cytokine regulation of pancreatic -cell function with special reference to the pathogenesis of type 1 diabetes

    Författare :Johnny Sternesjö; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; Diabetes; pancreatic islets; insulin secretion; cytokines; nitric oxide; streptozotocin; NOD mice; proteasome; nuclear factor-kappaB; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Sammanfattning : Cytokines produced by inflammatory cells have been implicated in the pathogenesis of type 1 diabetes. The overall aim of the present work was to test how different cytokines, supposed to be present in the insulitic lesion, could influence the function of islets of Langerhans. LÄS MER

  4. 3. Frk/Shb Signalling in Pancreatic Beta-cells : Roles in Islet Function, Beta-cell Development and Survival as Implicated in Mouse Knockout Models

    Författare :Björn Åkerblom; Michael Welsh; Hindrik Mulder; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medical cell biology; Medicinsk cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Sammanfattning : The adaptor protein Shb and the non-receptor tyrosine kinase Frk have been implicated in intracellular signalling in insulin-producing beta cells. In this thesis, knockout mice are used to further elucidate the role of Shb and Frk for beta cell number, cytokine-induced cell death, and glucose homeostasis. LÄS MER

  5. 4. Cell therapy for denervated tissue

    Författare :Roine El-Habta; Ludvig J. Backman; Paul J. Kingham; Patrik Danielson; António Salgado; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adipose tissue-derived stem cell; cell therapy; denervation; differentiation; myoblast; peripheral nerve injury; proliferation; regeneration; skeletal muscle; stromal vascular fraction; survival; tendon; cellforskning; cell research; Medical Cell Biology; medicinsk cellbiologi;

    Sammanfattning : Background: Peripheral nerve injury results in denervation of tendons and muscles. The biology of denervated muscle has been well studied but little is known about the associated tendons. LÄS MER

  7. 5. Towards sustainable urban transportation : Test, demonstration and development of fuel cell and hybrid-electric buses

    Författare :Anders Folkesson; Per Alvfors; Peter Treffinger; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; acceptance; analysis; auxiliary system; bus; Clean Urban Transport for Europe; concept; CUTE; demonstration; driver; drive cycle; duty cycle; energy flow; evaluation; fuel cell; heavy duty vehicle; hybrid management; hybrid vehicle; hydrogen; passenger; PEM; safety; Sankey diagram; series hybrid; sustainable; test; urban transport; vehicle simulation; acceptans; analys; hjälpaggregat; buss; Clean Urban Transport for Europe; koncept; CUTE; demonstration; körcykel; förare; energiflöde; utvärdering; bränslecell; tunga fordon; hybridsystemkontroll; hybridfordon; vätgas; passagerare; PEM; säkerhet; Sankey-diagram; seriehybrid; uthållig; hållbar; test; stadstransport; fordonssimulering; Vehicle engineering; Farkostteknik; Chemical engineering; Kemiteknik;

    Sammanfattning : Several aspects make today’s transport system non-sustainable: • Production, transport and combustion of fossil fuels lead to global and local environmental problems. • Oil dependency in the transport sector may lead to economical and political instability. LÄS MER