Sökning: "tertiary treatment"

Visar resultat 11 - 15 av 61 avhandlingar innehållade orden tertiary treatment.

1. 11. Design and Synthesis of Novel HIV-1 Protease Inhibitors Comprising a Tertiary Alcohol in the Transition-State Mimic

   Författare :Jenny Ekegren; Anders Hallberg; Daniel Rich; Uppsala universitet; []
   Nyckelord :Chemistry; HIV AIDS; HIV-1 protease inhibitor; transition-state mimic; tertiary alcohol; palladium; cross-coupling; aminocarbonylation; microwave; molybdenum hexacarbonyl; Kemi;

   Sammanfattning : HIV-1 protease inhibitors are important in the most frequently used regimen for the treatment of HIV/AIDS, the highly active antiretroviral therapy (HAART). For patients with access to this treatment, an HIV infection is no longer lethal, but rather a manageable, chronic infection. LÄS MER

3. 12. Analytical method development for ultra-trace determination of human pharmaceuticals in aqueous samples. Assessing the performance of a sewage treatment plant

   Författare :Saioa Zorita; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; molecularly imprinted solid-phase extraction; Sample preparation; solid-phase extraction; membrane extraction; human pharmaceuticals; sewage treatment plant; steroid hormones;

   Sammanfattning : Research focus in environmental pollution has recently been extended from more classical environmental pollutants such as PCBs or pesticides to pharmaceuticals and steroid hormones, which are designed to be biologically active and enter the environment primarily through regular domestic use. Consequently, it is important to monitor these substances concentrations in the effluents of sewage treatment plants (STPs) and in the environment in order to evaluate their associated risks. LÄS MER

4. 13. Antiretroviral treatment outcome and molecular epidemiology of HIV-1 subtype C drug resistance in Ethiopia

   Författare :Nigus Fikrie Telele; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Over the last decade, antiretroviral therapy (ART) has been rolled out in Ethiopia at a large scale. However, the outcome and aspects of drug resistance have been poorly studied at the national level. Also, the epidemic has been reported to be dominated by HIV-1 subtype C (HIV-1C), but this has not been verified at a nationwide level. LÄS MER

5. 14. Studies of molecular features and novel prognostic biomarkers of cutaneous melanoma

   Författare :Iva Johansson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; primary cutaneous melanoma; chronic sun-damage; chronic sun-damage skin; gene expression profiling; immunohistochemistry; tertiary lymphoid structures;

   Sammanfattning : Cutaneous malignant melanoma is a highly heterogeneous disease. Immunotherapy has revolutionized the treatment of stage IV disease and is now successfully administered as adjuvant treatment in stage III and soon in stage II. Correct identification of the patients at high risk for progressive disease who will benefit from the treatment is crucial. LÄS MER

7. 15. Antibody-based immunotherapy of cancer : From optimization to novel approaches

   Författare :Luuk van Hooren; Anna Dimberg; Eugene C. Butcher; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer immunotherapy; CD40; CTLA-4; PD-1; Gal-1; tertiary lymphoid structures;

   Sammanfattning : Antibody immunotherapy is a successful therapeutic approach to treat cancer. The overall aim of this thesis is to investigate the mechanisms of antibody-based immunotherapies and the role of the tumor microenvironment in mediating the anti-tumor immune response, in order to aid the development of improved immunotherapies for cancer patients. LÄS MER