Sökning: "terminal squamous differentiation"

Hittade 5 avhandlingar innehållade orden terminal squamous differentiation.

  1. 1. Modeling of multi-step oral carcinogenesis in vitro : assessment of growth, differentiation and apoptosis markers

    Författare :Annette Hansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Organotypic cultures; apoptosis; terminal squamous differentiation; buccal mucosa; cytokeratins; carcinogenesis; p53;

    Sammanfattning : Human oral mucosa, especially the buccal epithelium, is worldwide a common site for cancer. Cancer development frequently results in inactivation of tumor suppressor p53, a central regulator of growth and programmed cell death, and deregulated expression of structural elements like cytokeratins. LÄS MER

  3. 2. p63 – from expression to function : studies of normal oral mucosa and squamous cell carcinoma of the head and neck

    Författare :Niklas Thurfjell; Karin Nylander; Phillip Coates; Göran Roos; Luisa Guerrini; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; p63; SCCHN; p53; BRCA1; Pathology; Patologi;

    Sammanfattning : The human p63 gene discovered in 1997 encodes a series of protein isoforms that differ in their N- and/or C-terminal sequences. These isoforms have widely differing properties in promoting or repressing p53-related functions such as growth arrest and apoptosis. LÄS MER

  4. 3. Keratinocyte differentiation. Involvement of the growth hormon (GH)/insulinlike growth factor1 (IGFI) axis and IGF1 post receptor signaling

    Författare :Elisabeth Björntorp Mark; Göteborgs universitet; []
    Nyckelord :IGF1R; GH; Id1; keratinocytes; psoriasis;

    Sammanfattning : At cellular level, little is known about the genes that regulate keratinocyte differentiation andproliferation. Psoriasis is regarded as a T-cell mediated inflammatory disease with hyperproliferativekeratinocytes. LÄS MER

  5. 4. Understanding the role of non-coding RNAs in skin homeostasis and cancer

    Författare :Kunal Das Mahapatra; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The epidermis is a stratified epithelium with continuous self-renewing capacity. As the outermost layer of our body, it provides a protective barrier against external trauma, produces pigmentation, and keeps the skin hydrated. Keratinocytes are the primary constituent cells type within the epidermis. LÄS MER

  7. 5. Gene expression in buccal keratinocytes with emphasis on carbonyl metabolism

    Författare :Claudia A Staab; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The inner lining of the cheek, the buccal mucosa, is a target for air-borne, dietary and tobacco usage-derived carcinogens, but also interesting from a drug delivery point of view. Cancer arising in the buccal epithelium, buccal squamous cell carcinoma (BSCC), often diagnosed at a late disease stage, is highly aggressive and recurrent, emphasizing the need for novel approaches in diagnosis and therapy. LÄS MER