Sökning: "tau-phosphorylation"

Visar resultat 1 - 5 av 13 avhandlingar innehållade ordet tau-phosphorylation.

  1. 1. In vitro modelling of tau phosphorylating kinases : emphasis of Cdk5

    Författare :Anne Jämsä; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The main hallmarks of Alzheimer’s disease (AD) are extracellular deposits of betaamyloid (Aβ) and intracellular neurofibrillary tangles (NFT) composed of highly phosphorylated tau protein. Abnormal hyperphosphorylation of tau is the most deleterious step in NFT formation making the use of kinase inhibitors an attractive treatment possibility in AD. LÄS MER

  3. 2. Characterization of hippocampal slice cultures as model systems for neurodegenerative processes in Alzheimer's disease

    Författare :Sara Johansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer's disease (AD) is the most common cause of dementia and a growing health care problem worldwide. The disease affects different brain regions, including hippocampus, enthorhinal cortex, amygdala, neocortex and certain basal forebrain nuclei. Macroscopically, shrinkage of gyri and widening of sulci characterize the AD brain. LÄS MER

  4. 3. The involvement of degradation pathways and neuron-to-neuron transmission in Alzheimer’s disease

    Författare :Lotta Agholme; Martin Hallbeck; Katarina Kågedal; Jan Marcusson; Gunnar Gouras; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Although the vast majority of Alzheimer’s disease (AD) cases are of the sporadic type, mutations causing the familial form have been the focus of AD research for decades. The disease is pathologically characterised by β-amyloid (Aβ) and tau protein aggregates in neuritic plaques and neurofibrillary tangles. LÄS MER

  5. 4. Tau and neurofilament proteins in Alzheimer’s disease and related cell models

    Författare :Cecilia Björkdahl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :AD; tau; neurofilament proteins; kinases; zinc; Hsp27; alphaB-crystallin;

    Sammanfattning : Background and aims: Among those afflicted with dementia more than half suffer from Alzheimer’s disease (AD). Pathological hallmarks of the disease include aggregates of Abeta, so called amyloid plaques, and neurofibrillary tangles (NFTs) made up of hyperphosphorylated cytoskeletal proteins. LÄS MER

  7. 5. Beta-amyloid, tau-protein and cystatin C in the pathophysiology of Alzheimer´s disease

    Författare :Maj-Linda Selenica; Avdelningen för klinisk kemi och farmakologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurologi; neuropsykologi; neurofysiologi; neuropsychology; neurophysiology; Neurology; Medicine human and vertebrates ; Medicin människa och djur ; Clinical chemistry; Klinisk kemi; Kinase inhibitors; Tau protein; Cystatin C; Glycogen Synthase Kinase; Alzheimers Disease; Amyloid beta;

    Sammanfattning : Alzheimer´s Disease (AD) is a progressive neurodegenerative dementia characterized by the extracellular accumulation of the beta-amyloid (Ab) peptide into plaques and intracellular phosphorylation and accumulation of tau protein into neurofibrillary tangles (NFT). Inflammation due to astrocytic and microglial activation is one of the ongoing processes in the disease giving rise to cytokine production and oxidative stress. LÄS MER