Sökning: "tau protein"

Visar resultat 16 - 20 av 113 avhandlingar innehållade orden tau protein.

  1. 16. Prion-like Proteins in Neurodegeneration

    Författare :Tomas Roos; Experimentell demensforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Alzheimers och Parkinsons sjukdom är de vanligaste och näst vanligaste neurodegenerativa sjukdomarna som globalt drabbar ca 30 respektive 6 miljoner människor. I och med vår åldrande befolkning kommer det antalet bara att öka. LÄS MER

  3. 17. Molecular Mechanisms of Frontotemporal Lobar Degeneration

    Författare :Lena Skoglund; Anna Glaser; Martin Ingelsson; Lars Lannfelt; Stuart Pickering-Brown; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Frontotemporal lobar degeneration; Frontotemporal dementia; Tau; Progranulin; Alternative splicing; Nonsense-mediated decay; Haploinsufficiency;

    Sammanfattning : The aim of this thesis was to identify genetic factors involved in frontotemporal lobar degeneration (FTLD), a neurodegenerative disorder clinically characterised by a progressive change in personality, behaviour and language. FTLD is a genetically complex disorder and a positive family history is found in up to 40% of the cases. LÄS MER

  4. 18. Protein phosphatases and kinases implicated in Alzheimer's disease abnormal tau phosporylation

    Författare :Jin-jing Pei; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This thesis describes the distribution, levels and activities of a number of protein kinases and protein phosphatases (PPs) implicated in the abnormal phosphorylation of the tau protein that forms the paired helical filaments (PHFs) of Alzheimer's disease (AD) neurofibrillary tangles (NFTs). Paper I describes the immunocytochemical localization of PP-1, PP-2A, PP-2B and PTP-1B, as well as the protein kinase MAP kinase and p34cdc2 in the hippocampal formation of AD and control brains. LÄS MER

  5. 19. Prognostic subtypes in Parkinson’s disease and related disorders. Clinical, genetical, and biochemical markers for long-term social, motor, and cognitive development

    Författare :Emil Ygland Rödström; Lund Neurologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; parkinson s disease; prognosis; Neurofilament light chain; clinical subtype; motor phenotype; MAPT R406W mutation; frontotemporal dementia; enthorinal cortex; progressive supranuclear palsy; tau isoform; brain-gut hypothesis; proteoglycan recognition protein; PGLYRP; RUNDC3B;

    Sammanfattning : .... LÄS MER

  7. 20. Caspase activation in human neuroblastoma cells: mechanisms and spatiotemporal aspects

    Författare :Elena V. Ivanova; Kerstin Iverfeldt; Boris Zhivotovsky; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; apoptosis; caspase; local caspase activation; neurodegeneration; tau-anchored FRET sensors; tAFS; cancer; neuroblastoma; TNF-related apoptosis inducing ligand; TRAIL; protein kinase C; PKC; X-linked inhibitor of apoptosis protein; XIAP; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Apoptosis is one of the modes of programmed cell death, in which several members of the caspase family of proteases play the central role. However, activation of apoptotic caspases does not necessarily lead to cell death. LÄS MER