Sökning: "targeted therapy"

Visar resultat 16 - 20 av 323 avhandlingar innehållade orden targeted therapy.

  1. 16. CNS-Targeted Cell Therapy for Multiple Sclerosis

    Författare :Moa Fransson; Angelica Loskog; Tomas Olsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CAR; Targeting; Suppressive cells; Foxp3; Tregs; Clinical immunology; Klinisk immunologi; Immunologi; Immunology;

    Sammanfattning : Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system (CNS). In the current thesis, we have preformed an immunological investigation of patients with MS and developed an immunosuppressive cell therapy that could be beneficial for these patients. LÄS MER

  3. 17. The participation of older people with and without dementia in public space, through the lens of everyday technology use

    Författare :Sophie Nadia Gaber; Louise Nygård; Camilla Malinowsky; Anders Kottorp; Georgina Charlesworth; Agneta Malmgren Fänge; Karolinska institutet; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Participation in activities and places within public space has been linked to numerous health benefits and yet, little is known about participation among older people with and without dementia. Insights about participation in activities and places within public space can contribute to the somewhat ambiguous definition of participation, as “involvement in a life situation”, by acknowledging the complexity and interrelatedness of subjective, social, contextual, temporal, and technological aspects of participation. LÄS MER

  4. 18. Targeted monoclonal antibody therapy in chronic lymphocytic leukemia

    Författare :Claes Karlsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chronic lymphocytic leukemia (CLL) is still regarded as an incurable disease with a great need for developing new therapies and optimizing existing treatment options. The development of targeted therapy, i.e. therapy interfering with specific molecules needed for carcinogenesis and tumor growth, is rapidly evolving. LÄS MER

  5. 19. The Multiple Faces of Genetically-Modified T Cells : Potential Applications in Therapy

    Författare :Victoria Hillerdal; Magnus Essand; Johanna Olweus; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer immunotherapy; genetically engineered T cells; chimeric antigen receptor; T cell receptor; antigen-specific T cells; immunotherapy; Immunologi; Immunology; Klinisk immunologi; Clinical Immunology;

    Sammanfattning : In this PhD thesis the potential of T-cells as therapy for disease are explored. The applications of genetically modified T-cells for treatment of cancer and autoimmune disease; the functionality and optimal activation of T-cells are discussed. LÄS MER

  7. 20. Targeted therapy and outcome in chronic lymphocytic leukemia

    Författare :Sandra Eketorp Sylvan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Despite major advances, chronic lymphocytic leukemia (CLL) is still considered incurable. Fludarabine refractory patients and those with TP53disruptions have a particularly poor prognosis. Alemtuzumab is an established treatment option for these patients. However, its use is complicated by immunosuppressive side effects. LÄS MER