Sökning: "targeted biopsies"

Visar resultat 1 - 5 av 37 avhandlingar innehållade orden targeted biopsies.

  1. 1. PET and MRI of Prostate Cancer

    Författare :Catrin von Below; Håkan Ahlström; Cecilia Wassberg; Mauritz Waldén; Jens Sörensen; Michael Häggman; Joel Kullberg; Katrine Åhlström Riklund; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; lymph nodes; lymph node staging; PET CT; MRI DWI; extended pelvic lymph node dissection; targeted biopsies; multi-parametric MRI; TRUS guided biopsy; multiple regression analysis;

    Sammanfattning : Prostate cancer (PCa) is the most common non-skin malignancy of men in developed countries. In spite of treatment with curative intent up to 30-40% of patients have disease recurrence after treatment, resulting from any combination of lymphatic, hematogenous, or contiguous local spread. LÄS MER

  3. 2. Applying proteomics and metabolomics for studying human skeletal muscle with a focus on chronic trapezius myalgia

    Författare :Jenny Hadrévi; Albert Crenshaw; Fatima Pedrosa-Domellöf; Fredrik Hellström; Bijar Ghafouri; Mary F Barbe; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Trapezius myalgia; proteomics; 2D-DIGE; metabolomics; microdialysate; biopsies; anatomi; Human Anatomy;

    Sammanfattning : Work related musculoskeletal disorders are the dominating causes of reported ill-health in industrialized countries. These chronic pain conditions are one of the most costly public health problems in Europe and North America. LÄS MER

  4. 3. Liquid biopsies in pediatric oncology : towards clinical implementation

    Författare :Cecilia Arthur; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : During the last few years, liquid biopsies based on cell-free DNA (cfDNA) have become approved for clinical use in several areas of adult oncology. Due to the minimally invasive nature of this procedure, liquid biopsies could serve many purposes in childhood oncology as well. LÄS MER

  5. 4. Metastatic Breast Cancer: Biomolecular Characterization and Targeted Therapy

    Författare :Siker Kimbung; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metastatic breast cancer; biomarker conversion; liver metastasis-selective genes; prognosis; BRCA1; PARP1;

    Sammanfattning : Metastasis is a complex process that remains a major challenge in the clinical management of cancer, because most cancer-related deaths are attributed to disseminated disease rather than the primary tumor. Despite the significant advances in the prediction of prognosis, and therapeutic management of primary breast cancers, coupled with the substantial improvement in our understanding of the molecular determinants of metastasis, breast cancer relapse and death rates remain unacceptably high. LÄS MER

  7. 5. Ultrasensitive DNA sequencing using liquid biopsies enables precision medicine

    Författare :Gustav Johansson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Liquid biopsy; cell-free DNA; immune repertoire; next-generation sequencing; unique molecule identifier; GIST; γδ T cell;

    Sammanfattning : Liquid biopsies are minimally invasive and allow repetitive sampling of body fluids. Analysis of cell-free tumor DNA in liquid biopsies can be used as a biomarker for cancer. However, in most clinically relevant liquid biopsies, cell-free DNA is present at low concentrations, contains minute tumor allele frequencies, and is highly fragmented. LÄS MER