Sökning: "target prediction"

Visar resultat 11 - 15 av 165 avhandlingar innehållade orden target prediction.

1. 11. Cell cycle alterations and 11q13 amplification in breast cancer : prediction of adjuvant treatment response

   Författare :Marie Ahnström Waltersson; Olle Stål; Marie-Louise Fjällskog; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : The growth and development of the breast is to a large extent regulated by oestrogens through the oestrogen receptor (ER). Activation of the ERα triggers transcription of genes that are important for cell proliferation and stimulates entry into the G1 phase of the cell cycle. LÄS MER

3. 12. Selection of antigens for antibody-based proteomics

   Författare :Lisa Berglund; Mathias Uhlén; Sören Brunak; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; epitope; antigen; antibody; affinity; protein; proteome; proteomics; bioinformatics; prediction; primer design; sequence similarity; Bioengineering; Bioteknik;

   Sammanfattning : The human genome is predicted to contain ~20,500 protein-coding genes. The encoded proteins are the key players in the body, but the functions and localizations of most proteins are still unknown. LÄS MER

4. 13. Identifying the Potential of Combined Road Safety Interventions - A Method to Evaluate Future Effects of Integrated Road and Vehicle Safety Technologies

   Författare :Johan Strandroth; Chalmers tekniska högskola; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Evaluation; Road Safety Management; Autonomous Emergency Braking; Safety Performance Indicators; System Approach; Prediction; Integrated Safety; Vehicle Safety Technology;

   Sammanfattning : Health loss in the road transport system is one of the leading global public health problems with approximately 1.3 million people killed annually. In order to have a systematical approach to improved road safety, it has become common practice to form road safety management policies that include target setting and evaluation. LÄS MER

5. 14. An evolutionary basis for protein design and structure prediction

   Författare :Christoffer Norn; Biokemi och Strukturbiologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein evolution; Biophysics; Protein design; Protein structure prediction;

   Sammanfattning : The sequence diversity of protein families is a result of the biophysical selection pressures that shaped their evolutionary history. Among the dominant pressures is selection for protein thermostability, which in itself is an attractive target in protein engineering because of its importance for various biopharmaceutical properties, the performance of industrial enzymes, and the ability to design new protein functions. LÄS MER

7. 15. Computational Modelling in Drug Discovery : Application of Structure-Based Drug Design, Conformal Prediction and Evaluation of Virtual Screening

   Författare :Martin Lindh; Anders Karlén; Antti Poso; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; drug discovery; docking; virtual screening; tuberculosis; conformal prediction;

   Sammanfattning : Structure-based drug design and virtual screening are areas of computational medicinal chemistry that use 3D models of target proteins. It is important to develop better methods in this field with the aim of increasing the speed and quality of early stage drug discovery. LÄS MER