Sökning: "tRNA"
Visar resultat 16 - 20 av 100 avhandlingar innehållade ordet tRNA.
16. Design and Synthesis of Potential Aminoacyl-tRNA Synthetase Inhibitors
Sammanfattning : Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes present in all living organisms, their catalytic activity is involved in the translation of the genetic code into functional proteins and they are potential targets for anti-infective agents. The first step in the biosynthetic pathway catalysed by aaRSs consists of activation of the corresponding amino acid by the reaction with ATP to form an aminoacyl-adenylate (aa-AMP), the key intermediate in the biosynthesis of proteins. LÄS MER
17. Characterization of Amino Acid tRNA Ligases using the Analytical Ultracentrifuge
Sammanfattning : ABSTRACT. Quaternary structures of amino acid tRNA ligases/synthetases (aaRS) in the native as well as in denatured forms were examined by molecular weight determinations (paper I-IV). Analytical ultracentrifugation, gel electrophoresis, gel chromatography were used in these investigations. LÄS MER
18. Structural and functional basis of mitochondrial tRNA processing
Sammanfattning : The mammalian mitochondria are subcellular organelles, generating energy in the cell by the synthesis of adenosine triphosphate (ATP) via oxidative phosphorylation (OXPHOS). The maintenance of proper mitochondrial (mt) structure and function requires more than 1000 proteins generated from the nuclear DNA (nDNA) expression and 13 protein subunits generated from the mitochondrial DNA (mtDNA) expression. LÄS MER
19. Functional aspects of wobble uridine modifications in yeast tRNA
Sammanfattning : Transfer RNAs (tRNA) function as adaptor molecules in the translation of mRNA into protein. These adaptor molecules require modifications of a subset of their nucleosides for optimal function. The most frequently modified nucleoside in tRNA is position 34 (wobble position), and especially uridines present at this position. LÄS MER
20. Influence of the tRNA modification ms2i6A on codon translation
Sammanfattning : .... LÄS MER