Sökning: "t-PA"

Visar resultat 21 - 25 av 33 avhandlingar innehållade ordet t-PA.

1. 21. Beyond the established risk factors of myocardial infarction : lifestyle factors and novel biomarkers

   Författare :Patrik Wennberg; Jan-Håkan Jansson; Mai-Lis Hellénius; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lifestyle factors; physical activity; commuting activity; leisure time physical activity; occupational physical activity; snuff use; haemostatic markers; inflammatory markers; myocardial infarction; epidemiology; primary prevention.; Family medicine; Allmänmedicin; Family Medicine; allmänmedicin;

   Sammanfattning : Age, male sex, hypertension, smoking, diabetes, dyslipidaemia, and obesity are considered as established risk factors for cardiovascular diseases. Several of these established cardiovascular risk factors are strongly influenced by lifestyle. LÄS MER

3. 22. The significance of urokinase-type plasminogen activator (u-PA) in tumour growth and Linomide-induced upregulation of u-PA's endogenous inhibitor PAI-2

   Författare :Anita Billström; Lund Obstetrik och gynekologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reproduction; andrology; gynaecology; Obstetrics; roquinimex; Linomide; cancer; prostate cancer; PAI-2; plasmin; Plasminogen activators; u-PA; sexuality; Obstetrik; gynekologi; andrologi; reproduktion; sexualitet; Immunology; serology; transplantation; Immunologi; serologi;

   Sammanfattning : The progressive process of tumour invasion and generation of metastases is the primary cause of death for most patients with cancer. Some of the regulatory components of this progressive process are adhesion, migration, and proteolysis. LÄS MER

4. 23. Bacterial interaction with the fibrinolytic system and extracellular matrix

   Författare :Thomas Herrman Eberhard; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :plasminogen; extracellular matrix; basement membrane; virulence factors; fibronectin; vitronectin; collagen; Haemophilus influenzae Neisseria meningitidis Streptococcus pneumoniae;

   Sammanfattning : Bacterial infection of host organisms is a state of complex interaction between the parasite and the host. Two critical steps in the infectious process are: Adhesion to the epithelial surfaces and penetration of tissue barriers to gain entrance to tissues and into the circulation. These two steps have been the subjects of this thesis. LÄS MER

5. 24. Studies on the cultured human endothelial cell with special regard to clinical applicability

   Författare :Caroline Gillis-Hægerstrand; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The improvement of cardiovascular prosthetic materials, to reduce thrombus formation and inflammatory / immunological reactions, is a clinical challenge. Endothelial cell (EC) seeding using autologous cells to line the luminal surface of prosthetic materials has been suggested. LÄS MER

7. 25. Aspects of Plasminiogen Activator Inhibitor 1 in Metabolic Syndrome

   Författare :Karin Mossberg; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PAI-1; metabolic syndrome; obesity; type 2 diabetes; cardiovascular disease; fibrinolysis; thrombi; plasma; platelets; adipose tissue; mRNA; qPCR; reference gene;

   Sammanfattning : Plasminogen activator inhibitor 1 (PAI-1) is the main inhibitor of the fibrinolytic system and binds irreversibly to tissue-type plasminogen activator (t-PA), and thereby inhibits the protective action of t-PA against thrombus formation. Elevated levels of plasma PAI-1 is observed in subjects with type 2 diabetes (T2D) and the metabolic syndrome (MetS), which is a combination of metabolic features including obesity. LÄS MER