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Visar resultat 1 - 5 av 33 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Epigenetic influence on cardiovascular protective mechanisms in vivo: explorations of t-PA release and extracellular vesicle genetic content

    Författare :Kristina Svennerholm; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; myocardial ischemia; epigenetics; histone deactylase inhibition; t-PA; extracellular vesicles; ischemic preconditioning;

    Sammanfattning : ABSTRACT Background: Ischemic heart disease is one of the leading causes of death globally. This thesis explores endogenous mechanisms protecting against myocardial ischemia in context of epigenetics (changes in gene activity not caused by changes in DNA sequences). LÄS MER

  3. 2. Epigenetic regulation of gene expression in the vascular endothelium

    Författare :Mia Magnusson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; epigenetics; histone acetylation; DNA methylation; t-PA; PLAT; HUVECs; valproic acid; gene expression; enhancers;

    Sammanfattning : Epigenetic mechanisms, such as DNA methylation and histone modifications, constitute one way for a cell or an organism to respond to changes in the surrounding environment. While histone modifications are recognized to be quite dynamic, DNA methylation has been considered a more stable, or long-term, modification. LÄS MER

  4. 3. Cardioprotective treatment strategies

    Författare :Jesper vanderPals; Kardiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ADC-1004; apyrase; Cardioprotection; ischemia reperfusion; hypothermia; t-PA;

    Sammanfattning : In myocardial ischemia-reperfusion (I/R) injury, complement activation, tissue plasminogen activator (t-PA) and extracellular adenosine triphosphate (ATP) release contribute to myocardial injury. ATP is degraded into adenosine by the enzyme apyrase, and adenosine possesses cardioprotective properties. LÄS MER

  5. 4. Pharmacological stimulation of endothelial function and long-term impact of hypertension in man

    Författare :Ott Saluveer; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; t-PA; hypertension; fibrinolysis; endothelial function; valproic acid; histone deacetylase inhibitor; atorvastatin;

    Sammanfattning : Background: Ischemic heart disease is a major cause of death globally. Rupture of a coronary atherosclerotic plaque with occluding thrombus formation is the main cause of myocardial ischemia and infarction. LÄS MER

  7. 5. Coronary Reactive Hyperemia

    Författare :Göran Olivecrona; Kardiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kardiovaskulära systemet; Cardiovascular system; Medicin människa och djur ; Medicine human and vertebrates ; t-PA; P2Y1-receptors; Hypothermia; Coronary; Reactive hyperemia;

    Sammanfattning : Introduction: The mechanism of post ischemic reactive hyperemia is still unknown but now thought to be multifactorial and perhaps involving purinergic signalling. Purines such as ATP and ADP have recently been discovered to play a vital role in the regulation of vascular tone. LÄS MER