Sökning: "tår"

Visar resultat 1 - 5 av 10 avhandlingar innehållade ordet tår.

  1. 1. Health economics and its measures in rheumatoid arthritis

    Detta är en avhandling från Department of Clinical Sciences, Lund University

    Författare :Johan Karlsson; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cost-utility analysis; Cost-of-illness; Quality of life; EuroQol 5-Dimensions; Antirheumatic agents; TNF inhibition; Outcome assessment; Disease activity; Disability; Health economics; Rheumatoid arthritis;

    Sammanfattning : Objectives: To study: (I) the impact on cost-utility analyses of applying different national EuroQol 5-Dimensions (EQ-5D) preference sets; (II and III) whether, in methotrexate-refractory, early rheumatoid arthritis (RA), the addition of infliximab results in superior health-related quality of life (HRQoL) and may be considered cost-effective, as compared to adding sulfasalazine and hydroxychloroquine; (IV) how costs relate to disability (measured by the health-assessment questionnaire, HAQ), disease activity (28-joint disease activity score, DAS28) and HRQoL (EQ-5D) in RA. Methods: In the observational SSATG register, one-year quality-adjusted life-year (QALY) accumulation of two interventions was compared according to the UK, US, or Danish EQ-5D preference sets. LÄS MER

  2. 2. T cells, Cytokines, and Genetic Factors in Autoimmunity Studies of experimental models of arthritis and sialadenitis

    Detta är en avhandling från Medical Inflammation Research, Department of Experimental Medicine, Faculty of Medicine, Lund University

    Författare :Åsa Johansson; [2001]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; rheumatology locomotion; Collagen-induced arthritis Sialadenitis Mice Knockout Linkage analysis T cells Cytokines; muscle system; Skeleton; reumatologi; muskelsystem; Skelett;

    Sammanfattning : To understand the pathogenesis of autoimmune diseases we have to consider the problem from different angles. Animal models provide a tool to further understand these complex diseases, as the influence of genetic and environmental factors could be limited. LÄS MER

  3. 3. Primary Sjögren's Syndrome: Studies of DNA damage responses and autoantibodies

    Detta är en avhandling från Department of Laboratory Medicine, Lund University

    Författare :Gunnel Henriksson; [2001]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; autoantibodies; 18 ; t 14; cell cycle; p53; DNA-PK; DNA-binding protein; hypermutation; Sjögren s syndrome; DNA damage; anti-CD4 antibodies; Microbiology; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

    Sammanfattning : Primary Sjögren’s syndrome (SS) is a chronic autoimmune disease of unknown etiology. The disease primarily involves lachrymal and salivary glands, leading to dryness of the eyes and mouth, but a wide spectrum of exocrine and non-exocrine disease manifestations may be seen. LÄS MER

  4. 4. Skin fibrosis, internal organ involvement and auto antibodies in systemic sclerosis: longitudinal development and impact on survival

    Detta är en avhandling från Roger Hesselstrand, Department of Rheumatology, Lund University Hospital

    Författare :Roger Hesselstrand; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; muscle system; rheumatology locomotion; Skelett; muskelsystem; reumatologi; Skeleton; proteoglycan; pulmonary hypertension; organ involvement; auto antibodies; survival; systemic sclerosis; prognosis;

    Sammanfattning : Systemic sclerosis (SSc) is a connective tissue disease with a highly variable prognosis. Since new treatment strategies are emerging, there is a need for prognostic markers in order to help allocate patients to the optimal treatment. LÄS MER

  5. 5. Influence of leukotriene D4 and cyclooxygenase-2 on cell survival

    Detta är en avhandling från Katarina Wikström, Experimental Pathology, Lund University, U-MAS, Entrance 78, 205 02 Malmö

    Författare :Katarina Wikström; [2003]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pathological anatomy; Patologi allmän ; General pathology; colorectal cancer; inflammation; apoptosis; LTD4; COX-2; patologisk anatomi;

    Sammanfattning : The pro-inflammatory effect of leukotrienes is an important element in the pathogenesis of multiple disorders, including asthma and inflammatory bowel diseases (IBD). A serious concern for IBD patients is the increased risk of developing colorectal cancer and since there seems to be a general connection between inflammation and cancer we hypothesised that LTD4 induced signalling events could be involved in increasing the tumourgenic potential of cells. LÄS MER