Sökning: "systems genetics"

Visar resultat 11 - 15 av 182 avhandlingar innehållade orden systems genetics.

1. 11. Systems Biology of Yeast Lipid Metabolism

   Författare :Pramote Chumnanpuen; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Transcriptome; Integrated analysis; Lipidome.; Inositol-choline; Opi1; Yeast lipid metabolism; high throughput techniques; Ino4; TORC1; Snf1; Ino2;

   Sammanfattning : Lipid metabolism plays an important role in the development of many different life-style related diseases, such as type 2 diabetes and atherosclerosis, and understanding the molecular mechanisms behind regulation of lipid biosynthesis and degradation may lead to development of new therapies. In this project we undertook a global study of lipid metabolism in the eukaryotic model organism Saccharomyces cerevisiae. LÄS MER

3. 12. Novel Statistical Methods in Quantitative Genetics : Modeling Genetic Variance for Quantitative Trait Loci Mapping and Genomic Evaluation

   Författare :Xia Shen; Örjan Carlborg; Lars Rönnegård; William Hill; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; statistical genetics; quantitative trait loci; genome-wide association study; genomic selection; genetic variance; hierarchical generalized linear model; linear mixed model; random effect; heteroscedastic effects model; variance-controlling genes; Complex Systems – Microdata Analysis;

   Sammanfattning : This thesis develops and evaluates statistical methods for different types of genetic analyses, including quantitative trait loci (QTL) analysis, genome-wide association study (GWAS), and genomic evaluation. The main contribution of the thesis is to provide novel insights in modeling genetic variance, especially via random effects models. LÄS MER

4. 13. Site-Specific Recombination : Integrases, Accessory Factors and DNA Targets of P2-like Coliphages

   Författare :Lina Sylwan; Elisabeth Haggård-Ljungquist; Margaret C. M. Smith; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Genetics; Genetik; molekylärgenetik; Molecular Genetics;

   Sammanfattning : The temperate coliphage P2 and its family members integrate their genomes into the host Escherichia coli chromosome by a site-specific recombination mechanism to form lysogeny. Integration takes place between the complex phage attP site and the simple bacterial attB site and is catalyzed by the phage encoded integrase (Int). LÄS MER

5. 14. Site-specific recombination in P2-like coliphages

   Författare :Carlos Cardoso Palacios; Elisabeth Haggård-Ljungquist; Didier Mazel; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Genetics; Genetik; molekylärgenetik; Molecular Genetics;

   Sammanfattning : The scope of these studies has been to investigate the site-specific recombination systems of P2-like coliphages, both in an evolutionary perspective by a comparative analysis of related phages as well as in a functional perspective. Surveys of P2-like phages in Escherichia coli isolated from nature reveal the existence of seven discrete immunity classes and three integration sites, one of them previously unknown. LÄS MER

7. 15. The balance between sex and asex: evolutionary genetic studies of reproductive variation in Allium vineale

   Författare :Alf Ceplitis; Biologiska institutionen; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ontogeny; growth animal ; Allium vineale; Development biology; evolution; sexual reproduction; reproductive systems; embryology; Utvecklingsbiologi; ontogeni; embryologi; Genetics; cytogenetics; Genetik; cytogenetik;

   Sammanfattning : Evolutionary theory predicts a disadvantage to sexual reproduction. This manifests itself either by the higher growth rate of asexual females in a dioecious species, or by the higher transmission rate of a gene conferring asexual female function to its carriers in a hermaphrodite species. LÄS MER