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Visar resultat 1 - 5 av 182 avhandlingar som matchar ovanstående sökkriterier.
1. Using systems genetics to explore the complexity of leaf shape variation in Populus tremula
Sammanfattning : Leaves are essential for sustaining humanity as they function as the energy and oxygen-producing organ of plants. Intensive research on physiological processes has contributed immensely to our understanding of the function of leaves. However, comparatively little is known about how leaf size and shape is determined. LÄS MER
2. Computational discovery of antibiotic resistance genes and their horizontal transfer
Sammanfattning : Antibiotic resistance is increasing among clinical infections and represents one of the most serious threats to public health. Pathogens often become resistant by acquiring mobile antibiotic resistance genes (ARGs) via horizontal gene transfer (HGT). LÄS MER
3. Bioinformatics mining for disease causing mutations : using the dog genome as a model for human disease
Sammanfattning : Humans and dogs share many common diseases, and it has been shown that the identification of mutations that cause disease in dogs can help unravel the genetic basis for a similar disease in humans. Mapping of traits and disease in dogs is not a new idea, but the sequencing of the whole dog genome, the creation of a dense SNP maps followed by the development of SNP arrays for high throughput genotyping has led to new facilitated mapping procedures. LÄS MER
4. Tagging systems for sequencing large cohorts
Sammanfattning : Advances in sequencing technologies constantly improves the throughput andaccuracy of sequencing instruments. Together with this development comes newdemands and opportunities to fully take advantage of the massive amounts of dataproduced within a sequence run. LÄS MER
5. Systems Biology of the Secondary Metabolism in Filamentous Fungi
Sammanfattning : Filamentous fungi constitute a rich reservoir of pharmaceutically relevant bioactive small molecules. These compounds, commonly referred to as secondary metabolites, are widely used as antibiotics for the treatment of microbial infections, but also as other pharmaceuticals such as immunosuppressors, cholesterol lowering agents and anticancer drugs. LÄS MER