Sökning: "systemic lupus erythematosus"

Visar resultat 16 - 20 av 146 avhandlingar innehållade orden systemic lupus erythematosus.

1. 16. Susceptibility genes in systemic lupus erythematosus

   Författare :Anna Hellquist; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Systemic lupus erythematosus (SLE) is a complex autoimmune disease for which the incidence and prevalence vary between populations and also between males and females. SLE is characterized by production of pathogenic autoantibodies against nuclear antigens due to a breakdown in self-tolerance and the pathogenesis is associated with the formation of immune complexes, followed by tissue inflammation in multiple organs, such as the skin, joints, heart and kidneys. LÄS MER

3. 17. Cardiovascular disease in systemic lupus erythematosus

   Författare :Elisabet Svenungsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Premature cardiovascular disease (CVD) is a major cause of morbidity and mortality in systemic lupus erythematosus (SLE). This is an important clinical problem and a main objective of this study was to identify risk factors and underlying mechanisms. LÄS MER

4. 18. B cell depleting therapy in systemic lupus erythematosus

   Författare :Thórunn Jónsdóttir; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Systemic Lupus Erythematosus; Lupus nephritis; B cells; rituximab;

   Sammanfattning : Systemic Lupus Erythematosus (SLE) is a chronic autoimmune inflammatory disease characterized by multiple organ involvement, production of a wide range of autoantibodies and local formation or tissue deposition of immune complexes in the affected organs. Lupus nephritis (LN) is a common and serious organ involvement in patients with SLE. LÄS MER

5. 19. Studies on Neuropsychiatric Manifestations and Genetic Factors in Systemic Lupus Erythematosus

   Författare :Andreas Jönsen; Reumatologi och molekylär skelettbiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Skeleton; Genetics; Systemic Lupus Erythematosus; Neuropsychiatric; rheumatology locomotion; Skelett; muskelsystem; reumatologi; muscle system;

   Sammanfattning : Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disease encompassing a wide range of symptoms that can emanate from pathology in virtually any organ system. Severe SLE includes involvement of the central nervous system and kidneys. LÄS MER

7. 20. C-reactive protein (CRP) and anti-CRP autoantibodies in systemic lupus erythematosus : a study on the occurrence and clinical implications of anti-CRP antibodies and CRP-mediated complement activation

   Författare :Christopher Sjöwall; Thomas Skogh; Johan Frostegård; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; autoantibodies; complement activation; C-reactive protein; cytokines; immune complex; immunoregulation; opsonization; systemic lupus erythematosus; Rheumatology; Reumatologi;

   Sammanfattning : Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by production of a wide range of autoantibodies, multiple organ involvement and by local formation or tissue deposition of immune complexes (ICs) in the inflamed organs. In contrast to most systemic inflammatory conditions, and despite raised levels of pro-inflammatory cytokines, SLE flares are rarely reflected by elevated C-reactive protein (CRP), an important acute-phase reactant in man with homologs in vertebrates and several invertebrates. LÄS MER