Sökning: "systemic disease"

Visar resultat 1 - 5 av 702 avhandlingar innehållade orden systemic disease.

  1. 1. Systemic sclerosis : vascular, pulmonary and immunological aspects

    Författare :Grethe Neumann Andersen; Solbritt Rantapää Dahlqvist; Lucia Mincheva-Nilsson; Sören Jacobsen; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systemic sclerosis; interstitial lung disease; MMP-9; Th1 Th2; transcription factors; NO; iNOS; E-selectin; endothelium-dependent dilation; endothelium-independent dilation.; Rheumatology; Reumatologi;

    Sammanfattning : In systemic sclerosis (SSc), interstitial lung disease (ILD) and engagement of the vascular system lead to increased morbidity and mortality. The aim of this thesis was to elucidate, in a consecutively included cohort of SSc (limited and diffuse) patients (n = 33), the T cell cytokine profile driving the disease in ILD and to explore the role of matrix metalloproteinase 9 (MMP-9) and its inhibitor: tissue inhibitor of metalloproteinase 1 (TIMP-1) in the extracellular matrix (ECM) degrading process leading to fibrous scarring and honey combing. LÄS MER

  3. 2. Carotid artery disease : plaque features and vulnerability

    Författare :Fisnik Jashari; Michael Henein; Per Wester; Christine Kremer; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Carotid atherosclerosis; ultrasound; plaque features; echogenicity; calcification; surface plaque irregularities; subclinical atherosclerosis; cerebrovascular symptoms; Cardiology; kardiologi; cardiovascular disease; hjärt- och kärlforskning;

    Sammanfattning : Background: Atherosclerosis is an important cause of stroke. Ultrasound offers the convenience of real-time and detailed assessment of carotid plaque features as well as arterial wall thickening and composition. LÄS MER

  4. 3. Psoriatic arthritis: a complex disease : analyses on genetic and serological biomarkers and of comorbidity

    Författare :Kristina Juneblad; Gerd-Marie Alenius; Solbritt Rantapää-Dahlqvist; Lars-Erik Kristenssen; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Psoriatic Arthritis; genetics; inflammasomes; polymorphisms; biomarkers; disease expression; disease activity; cardiovascular diseases; mortality; epidemiology;

    Sammanfattning : Psoriatic Arthritis (PsA) is a heterogonous inflammatory arthritis associated with psoriasis. The disease leads to inflammation of peripheral joints, axial skeleton and/or enthesites, and can result in severe destruction of affected joints. LÄS MER

  5. 4. Cardiovascular disease in systemic sclerosis

    Författare :Annica Nordin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Systemic Sclerosis (SSc) is an autoimmune rheumatic disease, characterized by fibrosis of the skin and internal organs, vasculopathy and the production of autoantibodies. Cardiac and pulmonary disease manifestations are major causes of morbidity and mortality. LÄS MER

  7. 5. Cardiovascular Disease and Immune Mechanisms in Systemic Lupus Erythematosus

    Författare :Dag Leonard; Lars Rönnblom; Gunnel Nordmark; Maija-Leena Eloranta; Søren Jacobsen; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systemic Lupus Erythematosus; Cardiovascular Disease; Intima-Media Thickness; STAT4; IRF8; Interferon-α; Plasmacytoid dendritic cell; GM-CSF; IL-3; Medicin; Medicine; Genetics; Genetik; Immunologi; Immunology;

    Sammanfattning : Systemic lupus erythematosus (SLE) is an autoimmune, inflammatory disease characterized by autoantibody production and an activated type I interferon system. Cardiovascular disease (CVD) is as a major cause of morbidity and mortality. The aim of this thesis was to identify genetic risk factors for CVD in SLE. LÄS MER