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1. Stereoselective Synthesis of Amino Alcohols : Applications to Natural Product Synthesis
Sammanfattning : This thesis is divided into four separate parts with amino alcohols as the common feature. The first part of the thesis describes the development of an efficient three-component approach to the synthesis of α-hydroxy-β-amino esters. LÄS MER
2. Approaches to soft drug analogues of dihydrofolate reductase inhibitors : Design and synthesis
Sammanfattning : The main objective of the research described in this thesis has been the design and synthesis of inhibitors of the enzyme dihydrofolate reductase (DHFR) intended for local administration and devoid of systemic side-effects. The blocking of the enzymatic activity of DHFR is a key element in the treatment of many diseases, including cancer, bacterial and protozoal infections, and also opportunistic infections associated with AIDS (Pneumocystis carinii pneumonia, PCP). LÄS MER
3. Absolute Asymmetric Synthesis
Sammanfattning : Absolute asymmetric synthesis is the synthesis of optically active products from achiral or racemic precursors only. This has generally been regarded as impossible and is relevant in the discussion of the origins of biomolecular homochirality. LÄS MER
4. Parabolic Synthesis
Sammanfattning : Many consumer products, such as within the computer areas, computer graphics, digital signal processing, communication systems, robotics, navigation, astrophysics, fluid physics, etc. are searching for high computational performance as a consequence of increasingly more advanced algorithms in these applications. LÄS MER
5. Pheromone Synthesis : Conjugated Diene Systems and Oxygenated Carene Derivatives
Sammanfattning : .... LÄS MER