Sökning: "synonymous mutations"

Visar resultat 1 - 5 av 18 avhandlingar innehållade orden synonymous mutations.

  1. 1. Experimental Evolution : and Fitness Effects of Mutations

    Författare :Anna Knöppel; Dan I Andersson; Stanley Maloy; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Experimental evolution; Fitness effects; mutations; S20; fis; ribosome; horizontal gene transfer; adaptation; synonymous mutations; Mikrobiologi; Microbiology;

    Sammanfattning : Bacteria have small, streamlined genomes and evolve rapidly. Their large population sizes allow selection to be the main driver of evolution. With advances in sequencing technologies and precise methods for genetic engineering, many bacteria are excellent models for studying elementary questions in evolutionary biology. LÄS MER

  3. 2. Hereditary Colorectal Cancer; Identification, Characterization and Classification of Mutations

    Författare :Anna Rohlin; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hereditary Colorectal cancer; FAP; AFAP; mutations; mosaic mutation; exome sequencing; massively parallel sequencing; next generation sequencing; atypical polyposis; APC; POLE; GREM1; PPAP;

    Sammanfattning : Hereditary factors are thought to play are role in 20-30% of all colorectal cancers Around 6% are found as high penetrant disease-causing mutations in genes correlated to hereditary polyposis or hereditary non-polyposis syndromes. The aim of this thesis was to identify new causative genes and variants and also mutation mechanisms in families presenting a polyposis, atypical polyposis or nonpolyposis CRC phenotype. LÄS MER

  4. 3. Evolutionary Dynamics of Mutation and Gene Transfer in Bacteria

    Författare :Peter A Lind; Dan I Andersson; J. Arjan G. M. de Visser; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; fitness cost; bacterial evolution; gene amplification; mutational biases; GC content; synonymous substitutions; horizontal gene transfer; experimental evolution; Bacteriology; Bakteriologi; Microbiology; Mikrobiologi; Genetics; Genetik; Biology; Biologi; Mikrobiologi; Microbiology;

    Sammanfattning : The study of bacterial evolution is fundamental for addressing current problems of antibiotic resistance and emerging infectious diseases and lays a solid foundation for successful and rational design in biotechnology and synthetic biology. The main aim of this thesis is to test evolutionary hypotheses, largely based on theoretical considerations and sequence analysis, by designing scenarios in a laboratory setting to obtain experimental data. LÄS MER

  5. 4. Comparative Genomics in Birds

    Författare :Erik Axelsson; Hans Ellegren; Martin Lercher; Uppsala universitet; []
    Nyckelord :Molecular genetics; Birds; molecular evolution; macrochromosomes; microchromosomes; mutation rate; substitution rate; base composition; positive selection; genetic drift; population size; Genetik;

    Sammanfattning : To shed light on forces that shape the molecular evolution of bird genomes, and in turn avian adaptations, comparative analyses of avian DNA sequences are important. Moreover, contrasting findings in birds to those of other organisms will lend a clearer view on general aspects of molecular evolution. LÄS MER

  7. 5. Comparative Genomics of Endosymbiotic Bacteria

    Författare :Ivica Tamas; Paul Baumann; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; comparative genomics; endosymbiotic bacteria; Buchnera; reductive evolution; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Genomes of intracellular bacteria are thought to be the products of reductive evolution. They have evolved from ancestral genomes of free-living bacteria through a process of massive gene loss. LÄS MER