Sökning: "synapses"
Visar resultat 16 - 20 av 133 avhandlingar innehållade ordet synapses.
16. Coordination of endocytosis at the synaptic periactive zone
Sammanfattning : Neurons in the central nervous system communicate via specialized junctions called synapses. Neurotransmitter-filled vesicles are clustered at these junctions, where they are released in response to synaptic activity. To sustain reliable neurotransmission the synaptic vesicles are recycled locally. LÄS MER
17. Synaptic elimination and the complement system in Alzhaimer's disease
Sammanfattning : The mechanisms behind Alzheimer’s disease (AD) are largely unknown. The disease is to a large extent hereditary, and the best pathophysiological correlate to the severity of the symptoms is loss of synapses. LÄS MER
18. Cytoskeletal mechanisms in synaptic vesicle recycling
Sammanfattning : This thesis explores cytoskeletal mechanisms involved in the recycling of synaptic vesicles. As an initial step it characterizes synapses formed by giant reticulospinal axons in lamprey and defines their use as a model system. The most common type of reticulospinal synapse, "simple synapse", appeared to be most suitable as an experimental model. LÄS MER
19. Roles of SNAP-25 isoforms in activity-dependent long-term synaptic plasticity
Sammanfattning : SNARE proteins, SNAP-25, syntaxin 1A and VAMP2 constitute the functional units which join together to form the core SNARE complex. The SNARE complex carries out the vital function of membrane fusion of intracellular vesicles with plasma membranes, leading to the release of neurotransmitters in brain neuronal circuits and of hormones in endocrine glands. LÄS MER
20. Studies of membrane-binding proteins involved in synaptic vesicle recycling
Sammanfattning : Signaling between neurons occurs at synapses. A presynaptic nerve terminal releases neurotransmitter, which diffuses over the synaptic cleft, and binds to postsynaptic receptors. Release occurs by fusion of neurotransmitter-containing vesicles with the plasma membrane. LÄS MER