Sökning: "susceptibility loci"

Visar resultat 16 - 20 av 139 avhandlingar innehållade orden susceptibility loci.

1. 16. Candidate genes and chromosomal loci in multiple sclerosis

   Författare :Chun Xu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Multiple sclerosis (MS) is a demyelinating disorder of the central nervous system with a putatively autoimmune etiology. The pathophysiological basis of MS is incompletely known, although both genetic and environmental factors are presumed to be of importance. LÄS MER

3. 17. Molecular genetic studies of psoriasis susceptibility in 6p21.3

   Författare :Sofia Holm; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Complex disease; genetic; Psoriasis Susceptibility region 1 PSORS1 ; human leukocyte antigen C HLA-C ; linkage disequilibrium; major histocompatibility complex; single nucleotide polymorphism;

   Sammanfattning : Psoriasis is a common and chronic skin disease with multifactorial background. It affects approximately 2% of the Swedish population and is characterized by inflammatory and scaly lesions. The aetiology of psoriasis is not yet known, however, the genetic contribution to the disease is strong. LÄS MER

4. 18. Contribution of Immunogenetic Factors in Susceptibility to Cervical Cancer

   Författare :Emma Ivansson; Ulf Gyllensten; Patrik Magnusson; Allan Hildesheim; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medical genetics; Medicinsk genetik;

   Sammanfattning : Cervical cancer is the second most common cancer in women worldwide. Persistent infection by an oncogenic type of human papillomavirus (HPV) is a necessary but not sufficient cause and there is also a genetic component. LÄS MER

5. 19. Identification of Arthritis Susceptibility Genes in Mice and Humans

   Författare :Emma Ahlqvist; Immunologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunologi; transplantation; serology; Immunology; Medicin människa och djur ; Medicine human and vertebrates ; Biomedicinska vetenskaper; QTL; Biomedical sciences; Rheumatoid arthritis; Collagen-induced arthritis; serologi; Skeleton; muscle system; rheumatology locomotion; Skelett; muskelsystem; reumatologi; Clinical genetics; Klinisk genetik;

   Sammanfattning : Rheumatoid arthritis (RA) is a chronic autoimmune disease with a largely unknown aetiology. The risk of developing RA is partly dependent on genetic factors, which has motivated extensive efforts to identify the disease regulating genes as away to understand disease pathogenesis. LÄS MER

7. 20. Search for Type 2 Diabetes Susceptibility Genes Using Multiple Approaches

   Författare :Cecilia Lindgren; Malmö Institutionen för kliniska vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; single nucleotide polymorphism SNP ; transmission-disequilibrium test TDT ; genetic variation; single strand conformational polymorphism SSCP ; gene expression; insulin; glucose; genome-wide scan; linkage; genetic association; Type 2 diabetes; early onset diabetes EOD ; sekretion; diabetologi; Endokrinologi; diabetology; Endocrinology; secreting systems; signal-to-noise ratio SNR ;

   Sammanfattning : Type 2 diabetes mellitus is a multifactorial disorder characterized by chronic hyperglycemia resulting from pancreatic dysfunction and insulin resistance. It is a common disorder with a complex pattern of inheritance, likely to reflect the influence of multiple genetic and environmental factors on the diabetes risk. LÄS MER