Sökning: "suppressor"

Visar resultat 1 - 5 av 485 avhandlingar innehållade ordet suppressor.

1. 1. Neutrophils as Suppressor Cells and their role in Multiple Myeloma

   Författare :Julia Westerlund; Myelomgruppen; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Multiple myeloma; myelom; neutrophils; T-cells; immunology; suppressor cells; myeloid-derived suppressor cells;

   Sammanfattning : .... LÄS MER

3. 2. Functional Characterization of the Yeast Tumour Suppressor Homologue Sro7p

   Författare :Annabelle Forsmark; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Yeast; protein sorting; protein secretion; L 2 GL; tumour suppressor; SRO7; SRO77; ENA1; exocytosis; post-Golgi vesicles; ART5; E3 adaptor; ubiquitylation; ATLGL1; ATLGL2;

   Sammanfattning : Correct targeting of newly synthesized proteins to appropriate domains of the cell membrane is crucial to cellular architecture, polarity and function, making it no surprise that many proteins of the secretory machinery are conserved throughout evolution. This work presents a functional characterisation of the Saccharomyces cerevisiae cell polarity protein and tumour suppressor homologue, Sro7p. LÄS MER

4. 3. Cellular, Molecular and Functional Characterization of the Tumor Suppressor Candidate MYO1C

   Författare :Kittichate Visuttijai; Afrouz Behboudi; Katarina Ejeskär; Anders Oldfors; Volker Haucke; Högskolan i Skövde; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MYO1C; myosin IC; tumor suppressor gene; cancer; tumor; PI3K AKT signaling; Medical sciences; Medicin; MYO1C; myosin IC; tumor suppressor gene; cancer; tumor; PI3K AKT signaling;

   Sammanfattning : Tumor suppressor genes play a role as a growth regulator and a gatekeeper of a cell. Their inactivation is often detected in malignant tumors. Identification of novel tumor suppressor gene candidates may help to further understand tumorigenesis and aid in the discovery of a new treatment leading toward cure of cancer. LÄS MER

5. 4. On the role of the retinoblastoma tumor suppressor gene in hematopoietic differentiation

   Författare :Gösta Bergh; Helsingborg Kliniska Vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antisense; leukemia; cell cycle; differentiation; hematopoiesis; p16; p53; tumor suppressor genes; RB; oligonucleotides; Haematology; extracellular fluids; Hematologi; extracellulära vätskor;

   Sammanfattning : The aim of this study was to investigate the role of some tumor suppressor gene products (with emphasis on the retinoblastoma suppressor gene product) in the regulation of differentiation and proliferation in leukemic and normal hematopoietic cells. For this purpose, the expression of the tumor suppressor genes RB, p53 and p16 were artificially altered. LÄS MER

7. 5. On the Role of the Tumor Suppressor p53 in Leukemic Cell Differentiation

   Författare :Mats Ehinger; Tumörmikromiljö; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Haematology; p53; Tumor Suppressor Genes; Leukemia; Differentiation; extracellular fluids; Hematologi; extracellulära vätskor;

   Sammanfattning : Leukemic cells suffer from an impaired ability to differentiate due to inherited or acquired genetic lesions. These genetic changes can sometimes be bypassed with various compounds both in vitro, and, more rarely, in vivo, thus inducing terminal differentiation of the leukemic cells. LÄS MER