Sökning: "suppressor of cytokine signalling 3"

Hittade 3 avhandlingar innehållade orden suppressor of cytokine signalling 3.

1. 1. Uropathogenic Esherichia coli, multidrug-resistance and induction of host defense mechanisms

   Författare :Isak Demirel; Katarina Persson; Robert Kruse; Mirjana Poljakovic; Gabriela Godaly; Örebro universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Urinary tract infection; uropathogenic Escherichia coli; suppressor of cytokine signalling 3; nitric oxide; cytokines; extended-spectrum beta-lactamases; filamentation; IL-6; Biomedicin; Biomedicine;

   Sammanfattning : Uropathogenic Escherichia coli (UPEC) is the primary cause of urinary tract infection (UTI), which is one of the most common infections in humans. UPEC strains have acquired successful strategies to subvert the host defense and antibiotics to persist in the urinary tract. LÄS MER

3. 2. Investigations of Strategies to Counteract Proinflammatory Cytokines in Experimental Type 1 Diabetes

   Författare :Andreas Börjesson; Stellan Sandler; Annika Carlsson; Jens Nielsen; Uppsala universitet; []
   Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Type 1 diabetes; proinflammatory cytokines; SOCS-3; pancreatic islets; inducible nitric oxide synthase; insulin secretion; NOD mice; islet transplantation; proinsulin conversion; streptozotocin; prolactin; Medicine; Medicin;

   Sammanfattning : Type 1 diabetes (T1D) is a chronic autoimmune disease targeted against the pancreatic β-cells. Proinflammatory cytokines are considered to play a major role in the destruction of the insulin-producing β-cells. This thesis studied strategies to counteract proinflammatory cytokines in experimental T1D. LÄS MER

4. 3. The Myc network of growth regulators and its interplay with growth and differentiation signals

   Författare :Siqin Wu; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Myc; Mad1; p21Cip1; phorbol ester; IFN-g; TGF-b; differentiation; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

   Sammanfattning : The proto-oncogenes/tumor suppressor genes of the Myc/N4ax/Mad network encode transcription factors that are important regulators of cell growth, differentiation, and apoptosis and that are frequently implicated in tumor development. Regulation of their biological functions by growth/differentiation signals as well as their interplay with growth/differentiation signalling pathways play important roles in cell fate determination. LÄS MER