Sökning: "suppressing gene"

Visar resultat 6 - 10 av 46 avhandlingar innehållade orden suppressing gene.

  1. 6. Neuropeptides and neurotrophic factors in epilepsy: seizure suppressant actions of VEGF, NPY and galanin

    Författare :Litsa Nikitidou; Lund Neurologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epilepsy; Gene Therapy; Neuropeptide Y; Y2 receptor; Y5 receptor; Galanin; Encapsulated cell biodelivery; Vascular endothelial growth factor; Flk-1; Hippocampus;

    Sammanfattning : Epilepsy is a severe chronic neurological disorder, affecting about 1% of the population. The disease is manifested by spontaneous recurrent seizures, caused by hypersynchronized neuronal activity due to imbalance in the brain between the inhibition and excitation. LÄS MER

  3. 7. Alternative pathways in the plant respiratory chain -transgenic analyses of type II NAD(P)H dehydrogenases

    Författare :Sabá Wallström; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : During oxidative phosphorylation, the production of ATP is driven by the activity of several proton-pumping respiratory protein complexes. In plants, non-proton pumping type II NAD(P)H dehydrogenases are also present in the respiratory chain to oxidize cytosolic and matrix NAD(P)H. LÄS MER

  4. 8. Genetic Alterations in Pheochromocytoma and Paraganglioma

    Författare :Jenny Welander; Peter Söderkvist; Oliver Gimm; Mercedes Robledo; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pheochromocytoma; paraganglioma; genetics; sequencing; cancer; mutation;

    Sammanfattning : Pheochromocytomas and paragangliomas are neuroendocrine tumors that arise from neural crest-derived cells of the adrenal medulla and the extra-adrenal paraganglia. They cause hypertension due to an abnormally high production of catecholamines (mainly adrenaline and noradrenaline), with symptoms including recurrent episodes of headache, palpitations and sweating, and an increased risk of cardiovascular disease. LÄS MER

  5. 9. Body fat regulating neuropeptides: relation to interleukines and gut microbiota

    Författare :Erik Schéle; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IL-6; IL-6 receptor a; obesity; hypothalamus; brainstem; immunohistochemistry;

    Sammanfattning : Previous studies have shown that mice lacking interleukin-6 (IL-6), an important cytokine in the immune system, develop obesity, and that central, but not peripheral, administration of IL-6 induces energy expenditure. These findings suggest that IL-6 suppresses fat mass through the central nervous system. LÄS MER

  7. 10. Enzymatic Regulation of Steroidogenesis and Nuclear Receptor Activation : Special Focus on Vitamin D and Sex Hormones

    Författare :Johan Lundqvist; Kjell Wikvall; Maria Norlin; Magnus Ingelman-Sundberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adrenal steroidogenesis; CYP7B1; vitamin D; calcitriol; enzymatic regulation; transcriptional regulation; CYP21A2; aromatase; sex hormone; estrogen; androgen; nuclear receptor; Pharmaceutical biochemistry; Farmaceutisk biokemi; Farmaceutisk biokemi; Pharmaceutical Biochemistry;

    Sammanfattning : Enzyme-catalyzed reactions are important to regulate steroidogenesis and nuclear receptor activation. The present investigation examines the role of steroid metabolism catalyzed by CYP7B1 for regulation of hormone receptor activation and the effects of vitamin D on enzymatic regulation of steroidogenesis. LÄS MER