Sökning: "superfamily"

Visar resultat 1 - 5 av 223 avhandlingar innehållade ordet superfamily.

  1. 1. Quantum chemical modeling of enzymatic reactions : applications to the tautomerase superfamily

    Författare :Robin Sevastik; Fahmi Himo; Margaretha Blomberg; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Bioengineering; Bioteknik;

    Sammanfattning : In this thesis, quantum chemical methods are used to investigate enzymatic reaction mechanisms. The Density functional theory, in particular the hybrid B3LYP functional, is used to model two enzymes belonging to the tautomerase superfamily; 4-Oxalocrotonate Tautomerase (4-OT) and cis-Chloroacrylic Acid Dehalogenase (cis-CAAD). LÄS MER

  3. 2. Gene regulation by different proteins of TGFβ superfamily

    Författare :Varun Maturi; Aristidis Moustakas; Anita Göndör; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; EMT; Snail1; ZEB1; TGFβ; BMP; Gene regulation;

    Sammanfattning : The present thesis discusses how gene regulation by transforming growth factor β (TGFβ) family cytokines is affected by post-translational modifications of different transcription factors. The thesis also focuses on gene regulation by transcription factors involved in TGFβ signaling. LÄS MER

  4. 3. Computational exploration of the medium-chain dehydrogenase/reductase superfamily

    Författare :Linus J Östberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The medium-chain dehydrogenase/reductase (MDR) superfamily is a protein family with more than 170,000 members across all phylogenetic branches. In humans there are 18 representatives. LÄS MER

  5. 4. Molecular characterization and evolution of alpha-actinin : from protozoa to vertebrates

    Författare :Ana Virel; Lars Backman; Kristina Djinovic-Carugo; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; alpha-actinin; evolution; spectrin repeat; intragene duplication; phylogenetic tree; spectrin superfamily; Biochemistry; Biokemi;

    Sammanfattning : alpha-actinin is a ubiquitous protein found in most eukaryotic organisms. The ability to form dimers allows alpha-actinin to cross-link actin in different structures. In muscle cells alpha-actinin is found at the Z-disk of sarcomeres. LÄS MER

  7. 5. Cell signaling by Rho and Miro GTPases : Studies of Rho GTPases in Cytoskeletal Reorganizations and of Miro GTPases in Mitochondrial Dynamics

    Författare :Åsa Fransson; Pontus Aspenström; Harry Mellor; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ras superfamily; Rho GTPases; cytoskeleton; Miro GTPases; mitochondrial dynamics; Cell and molecular biology; Cell- och molekylärbiologi;

    Sammanfattning : The Ras superfamily of GTPases embraces six major branches of proteins: the Ras, Rab, Ran, Arf, Rho and Miro subfamilies. The majority of GTPases function as binary switches that cycle between active GTP-bound and inactive GDP-bound states. This thesis will focus primarily on the biological functions of the Rho and Miro proteins. LÄS MER