Sökning: "supercoiling"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet supercoiling.

  1. 1. Kinetic Recognition of Nucleic Acids - Studies on the DNA Binding Selectivity of Threading Ruthenium Complexes

    Författare :Pär Nordell; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; intercalation; circular dicroism; ruthenium complexes; sequence selectivity; fluorescence; DNA; supercoiling; spectroscopy; kinetics;

    Sammanfattning : Despite the great progress in our understanding of DNA during the past half-century, there are many important aspects of its chemical and biological role yet to be explored. The principles by which it selectively interacts with other molecules have attracted much interest due to the relevance for fundamental cellular processes, as well as for the development of diagnostic probes and effective pharmaceutical agents. LÄS MER

  3. 2. Unravelling Mechanistic Insights of Eukaryotic Transcriptional Control

    Författare :Johanna Hörberg; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Transcriptional control; Gene expression regulation; DNA supercoiling; DNA methylation; DNA-protein recognition; Basic-Leucine-Zipper transcription factors; Basic-Helix-Loop-Helix transcription factors; Sequence specific DNA plasticity; Transcription factor cooperativity; Cancer; Molecular modelling; Molecular dynamics;

    Sammanfattning : DNA transcription involves the association of multiple proteins with DNA to convert the genetic information into messenger-RNA transcripts, which later will be translated into proteins. Con-trolled regulation of transcription is imperative for preserving the healthy and homeostatic state of cells. LÄS MER

  4. 3. DNA topoisomerases and nucleosome dynamics in fission yeast

    Författare :Ulrika Norman Axelsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The organization of DNA and associated proteins into chromatin allows for compaction and protection of large eukaryotic genomes. However, it also poses a challenge to fundamental cellular processes such as DNA replication, recombination, repair and transcription. LÄS MER

  5. 4. Signal Transduction in Photoreceptor Proteins : Insights From Time-Resolved X-ray Solution Scattering

    Författare :Oskar Berntsson; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Signal transduction; Photoreceptor; Time-resolved X-ray solution scattering; Protein dynamics; Phytochrome; Light-oxygen-voltage; Cryptochrome;

    Sammanfattning : The ability to sense and react to different light conditions is of great importance for many organisms on the face of the earth. Specialized proteins known as photoreceptor proteins provide bacteria, plants and animals with this ability. LÄS MER

  7. 5. Investigating novel roles of topoisomerase regulatory interactions in transcription

    Författare :Vladislav Kuzin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Drugs targeting DNA Topoisomerases (TOPs, TOP1 and TOP2) are mainstays of anti-cancer therapy. While they have proven effective, the toxicity of current TOP drugs caused by DNA damage-induced apoptosis of non-cancer cells, limits their use in the clinic. LÄS MER