Sökning: "sun: activity"

Visar resultat 1 - 5 av 67 avhandlingar innehållade orden sun: activity.

  1. 1. Studies of b-AP15 : a novel inhibitor of proteasome deubiquitinase activity

    Författare :Chao Sun; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Bortezomib was the first FDA approved proteasome inhibitor that was initially very successful in treatment of multiple myeloma patients but acquired resistance and adverse side-effect highly decreased patients’ quality of life. Development of 2nd generation proteasome inhibitors that could overcome these shortcomings is thus of prime medical importance. LÄS MER

  3. 2. Characterization of regulatory factors controlling tip growth in Nicotiana tabacum pollen tubes

    Författare :Jia Sun; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Rho GTPases constitute a family of highly conserved signaling proteins with key functions in the regulation of cellular polarization and polar cell growth. In plants, Rho GTPases are represented by a plant specific subfamily referred to as Rac/Rop GTPases. LÄS MER

  4. 3. Studies of enzymes in mitochondrial DNA precursor synthesis : regulatory mechanisms for human thymidine kinase 2 and deoxyguanosine kinase

    Författare :Ren Sun; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : As important enzymes in mitochondrial nucleotide salvage pathway, thymidine kinase 2 (TK2) and deoxyguanosine kinase (dGK) are expressed constitutively in almost all cells. These two enzymes catalyze the initial rate-limiting phosphorylation of pyrimidine and purine deoxynucleosides, respectively, providing DNA precursors for mitochondrial DNA (mtDNA) replication. LÄS MER

  5. 4. Intestinal Ischemia and Reperfusion Injury - Pathophysiology as basis for novel treatment

    Författare :Zhengwu Sun; Lund Kirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; organ dysfunction; epithelium; endothelium; adhesion molecules; cytokines; protease inhibitor; Intestine; barrier; Surgery; orthopaedics; traumatology; Kirurgi; ortopedi; traumatologi;

    Sammanfattning : Intestinal ischemia and reperfusion (I/R) is not infrequent in the clinical situation and the intestinal barrier plays an important role in gut barrier function, preventing not at least septic complications and potentially the development of the multiple organ dysfunction syndrome. Mechanisms of intestinal I/R induced gut epithelial and endothelial barrier dysfunction and remote organ dysfunction, as well as potential preventive and therapeutic modes of management were evaluated in the rat. LÄS MER

  7. 5. Microsomal glutathione transferase : studies on the kinetic mechanism, species variety, binding properties and substrate measurement

    Författare :Tie-Hua Sun; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Microsomal glutathione transferase (MGST) is a membrane bound detoxification enzyme, which has been purified from different species including rat, mouse, human, frog, and fish. The rat MGST1 is localized predominantly in the liver microsomes and the outer mitochondrial membrane. LÄS MER