Avancerad sökning

Hittade 5 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Identification of new disease mechanisms and treatments for type 2 diabetes based on genetic variants and gene expression networks

    Författare :Annika Axelsson; Diabetes - öpatofysiologi; []
    Nyckelord :Type 2 diabetes; insulin; ADRA2A; genotype; gene network analysis; SOX5; drug repositioning; sulforaphane; clinical study; typ 2-diabetes; insulin; ADRA2A; genotyp; gennätverksanalys; SOX5; sulforafan; klinisk studie;

    Sammanfattning : Improved understanding of the disease mechanisms underlying type 2 diabetes (T2D) is needed, and so are new treatments.A new T2D risk variant was recently identified in ADRA2A, which encodes the α2A-adrenergic receptor. LÄS MER

  3. 2. Reactive gliosis in the injured brain: The effect of cell communication and Nrf2-mediated cellular defence

    Författare :Heléne Andersson; Göteborgs universitet; []
    Nyckelord :Keywords: astrocyte; gap junction; Hmox1; microglia; Nrf2; Nqo1; oxidative stress; reactive gliosis;

    Sammanfattning : Stroke and other brain injuries trigger an extensive glial cell response referred to as reactive gliosis. Reactive gliosis is characterized by hypertrophic and proliferating astrocytes, proliferating microglia and NG2-positive cells, which eventually form a bordering glial scar around the damaged area. LÄS MER

  4. 3. Measurement of sensitivity to DNA damaging agents

    Författare :Sherin T Mathew; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; intrinsic sensitivity; DNA damage; ionizing radiation; cell division;

    Sammanfattning : There is a large inter-individual variation in intrinsic sensitivity in patients receiving treatment with DNA damaging agents. Cancer therapy exemplifies this problem where patients experience varying degree of normal tissue side effects in response to radiation or chemotherapy. LÄS MER

  5. 4. Plant pathogen defense: Signalling, resistance and cell death

    Författare :Oskar N. Johansson; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Pseudomonas; cell death; pathogens; plant defense; hypersensitive response; glycolipid; reactive oxygen species; blumeria graminis; erysiphe pisi;

    Sammanfattning : Pathogenic microorganisms are present everywhere in nature and infect both animals and plants. Phytopathogenic microorganisms cause diseases on plants, and are responsible for crop loss amounting in the order billions of dollars annually. LÄS MER

  7. 5. Astrocytic communication and cell death during metabolic depression and oxidative stress

    Författare :Christina Nodin; Göteborgs universitet; []
    Nyckelord :astrocyte; gap junction; ATP; ROS; oxidative stress; Annexin V; AIF; programmed cell death; Nrf2; scavenger; iodoacetate; SIN-1;

    Sammanfattning : Stroke is a major cause of death and adult disability in the western world. Most often, stroke is caused by the occlusion of a brain artery. Within the perfusion territory of the occluded vessel, various degrees of necrotic and delayed programmed cell death will occur if the occlusion persists, leading to expanding tissue damage. LÄS MER