Sökning: "sulfonylureas"

Visar resultat 1 - 5 av 10 avhandlingar innehållade ordet sulfonylureas.

  1. 1. The Synthesis and Use of Certain Pyridine Derivatives as Modulators of the G-protein Coupled Receptors mGlu5 and P2Y12

    Författare :Peter Bach; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; mGluR5; P2Y12; gastroesophageal reflux disease GERD ; thrombosis; ethyl nicotinates; ureas; sulfonylureas; oxazoles; bioisosteres; regioselectivity; solvent effect.;

    Sammanfattning : The glutamatergic mGlu5 receptor and the purinergic P2Y12 receptor are two important targets in the development of novel treatments of gastroesophageal reflux disease (GERD) and thrombosis, respectively. Synthesis was developed to investigate the structure-activity relationships (SAR) of a novel series of 2-alkynylpyridine derivatives as mGluR5 antagonists. LÄS MER

  3. 2. Sodium handling by the pancreatic ß-cell : effects of glucose, sulfonylureas and neuroreceptor agonists

    Författare :Samir Saha; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  4. 3. Effects of glucose and sulfonylureas on sodium in pancreatic islets

    Författare :Liaquat Ali; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  5. 4. Effects of glucose and sulfonylureas on Ca2+ entry and on sodium content of pancreatic islets

    Författare :Nils Wesslén; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  7. 5. Protein phosphorylation cascades regulating islet beta-cell insulin exocytosis through glucose sensing and drug signaling : with special focus on serine/threonine protein phosphates and hypoglycemic sulfonylureas

    Författare :Mikael Lehtihet; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Diabetes; Islet; Insulin; Exocytosis; Protein phosphatase; Protein kinase; CPT-1; Sulfonylurea; Glutamate; Polyphosphoinositide;

    Sammanfattning : In human type 2 diabetes, loss of glucose-sensitive insulin secretion from the pancreatic �-cell is an early pathogenetic event. Initially, this may be compensated for by stimulating insulin secretion by sulfonylurea drugs. LÄS MER