Sökning: "sulfonylurea"

Visar resultat 6 - 10 av 18 avhandlingar innehållade ordet sulfonylurea.

1. 6. Pharmacoepidemiologic Studies of Diabetes Mellitus - with special reference to - Glucose Control and Prognosis of Type 2 Diabetes

   Författare :Jonny Olsson; Samhällsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetology; secreting systems; Endocrinology; cohort study; longitudinal study; cross-sectional study; mortality; diabetes mellitus; Pharmacoepidemiology; prevalence; type 2 diabetes; diabetes costs; short-term sick-leave; premature retirement; production losses; inpatient care; glycaemic control; fasting blood glucose; oral antihyperglycaemic agents; sulphonylurea; metformin; insulin; combination treatment; drug utilization; prescribed daily doses; safety; effectiveness; Endokrinologi; sekretion; diabetologi;

   Sammanfattning : The efficacy and safety of antihyperglycaemic drugs have been evaluated in one American and one British randomized clinical trial, which have given contradictory results. The positive results of the latter may be more convincing as it included a greater number of patients and as its duration was longer. LÄS MER

3. 7. Insulin treatment of elderly type 2 diabetic patients

   Författare :Jonas Tovi; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Type 2 diabetes; elderly; insulin treatment; costs; ambulatory blood pressure; monitoring; well-being; symptoms; polyneuropathy; IGFBP-1 IGF-I; retinopathy;

   Sammanfattning : In this study, the effect of improved metabolic control through insulin treatment was investigated in elderly patients with type 2 diabetes with secondary failure of oral treatment. Forty, consecutive, elderly patients (mean age 75.3 (5.9) (mean and SD), range 67-86 years) were studied. LÄS MER

4. 8. Metabolic signals and the ATP-sensitive potassium channel in the pancreatic beta-cell

   Författare :Robert Bränström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :ATP-regulated K channel; pancreatic [beta]-cell oscillations; [alpha]-ketoisocaproate; long chain acyl-CoA esters; Kir6.2 SUR1 structure-function.;

   Sammanfattning : ATP-sensitive K+ (KATP) channels are widely distributed in a variety of tissues and cell types. KATP channels are comprised of two subunits, a pore forming subunit (Kir6.x) and a regulatory sulfonylurea receptor (SURx). Both subunits are required for fully functional channels. LÄS MER

5. 9. Ecological effects of pesticides in freshwater model ecosystems

   Författare :Lina Wendt-Rasch; Biologiska institutionen; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; marine biology; aquatic ecology; limnology; Marinbiologi; Hydrobiology; community; zooplankton; algae; herbicide; insecticide; pesticide mixture; macrophytes; cypermethrin; metsulfuron-methyl; risk assessment; pesticides; microcosms; limnologi; akvatisk ekologi;

   Sammanfattning : In this thesis I have investigated the effects of pesticide exposure on the ecosystem level using various types of experimental ecosystems, i.e. microcosms. The direct effect of exposure to cyperemthrin, a pyretroid insecticide, was a rapid decrease of crustancean zooplankton in enclosures in a lake. LÄS MER

7. 10. Mechanisms of insulin exocytosis and release

   Författare :Sebastian Barg; Islet cell physiology; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ClC-3; electrophyiology; confocal microscopy; calcium channel; readily releasable pool; exocytosis; insulin; diabetes; green fluorescent protein; Physiology; Fysiologi;

   Sammanfattning : Endocrine cells as well as neurons release their hormones and transmitters by regulated exocytosis. In the pancreatic B-cell, stimuli like glucose initiate biochemical and electrical processes that culminate in influx of Ca2+, which then triggers exocytosis of insulin-containing granules. LÄS MER