Sökning: "subunit interactions"

Visar resultat 1 - 5 av 113 avhandlingar innehållade orden subunit interactions.

  1. 1. Quaternary structure and interaction approaches to allosteric regulation of class I ribonucleotide reductases

    Författare :Mikael Crona; Britt-Marie Sjöberg; Mark Meuth; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ribonucleotide reductase; allosteric regulation; quaternary structure; subunit interactions; enzyme activity; SPR; GEMMA; Molecular biology; Molekylärbiologi; Molecular Biology; molekylärbiologi;

    Sammanfattning : Deoxyribonucleic acid (DNA) chains in which our genetic blueprint is stored are built from four DNA precursors by DNA polymerases. The enzyme ribonucleotide reductase (RNR) provides the only de novo synthesis pathway of deoxyribonucleotides from ribonucleotides and is essential for nearly all organisms. LÄS MER

  3. 2. Molecular principles of protein stability and protein-protein interactions

    Författare :Christofer Lendel; Per-Åke Nygren; Christopher M. Dobson; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; affibody; binding thermodynamics; induced fit; molten globule; NMR spectroscopy; protein engineering; protein-protein interactions; protein stability; protein structure.; Structural biochemistry; Strukturbiokemi;

    Sammanfattning : Proteins with highly specific binding properties constitute the basis for many important applications in biotechnology and medicine. Immunoglobulins have so far been the obvious choice but recent advances in protein engineering have provided several novel constructs that indeed challenge antibodies. LÄS MER

  4. 3. Identification of SLiMs: Mapping and characterizing motif-based protein interactions

    Författare :Muhammad Ali; Ylva Ivarsson; Shoshana Wodak; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Phage display; protein-protein interactions; short linear motifs; PDZ; FERM; affinity; x-ray crystallization; molecular docking; NLS;

    Sammanfattning : During the last twenty years it has become evident that about 35-40% of amino acids in the proteome are in regions that have evolved to remain unstructured. These intrinsically disordered regions contain short linear motifs (SLiMs), which serve as docking sites for protein-protein interactions. LÄS MER

  5. 4. Protein modularity : Structure and interactions by NMR and SPR

    Författare :Amélie Wallenhammar; Maria Sunnerhagen; Björn Wallner; Lotta Tollstoy-Tegler; Helena Berglund; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Protein degradation is a fundamental cornerstone of regulation of protein levels in the human body. For proper function, numerous molecular processes rely on fine-tuned communication through specific interactions between proteins. LÄS MER

  7. 5. Dynamics of protein folding and subunit interactions in assembly of the yeast mediator complex

    Författare :Zaki Shaikhibrahim; Stefan Björklund; Bengt-Harald Jonsson; Umeå universitet; []
    Nyckelord :mediator; transcriptional regulation; assembly; folding; MEDICINE; MEDICIN; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : The Mediator complex was originally discovered in the yeast Saccharomyces cerevisiae and has since then been shown to be required for transcriptional regulation both in vitro and in vivo. The Mediator complex also stimulates basal, unregulated transcription and serves as a bridge by conveying signals from promoter-bound transcriptional regulatory proteins such as activators and repressors to the RNA Polymerase II general transcriptional machinery. LÄS MER