Sökning: "subtilisin"

Visar resultat 21 - 25 av 25 avhandlingar innehållade ordet subtilisin.

  1. 21. Genetic and metabolic studies of APOE, PCSK9, TM6SF2 and PNPLA3

    Författare :Hovsep Mahdessian; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Lipids – including fatty acids (FAs), triglycerides (TGs), cholesterol and cholesterol esters (CEs) – are hydrophobic molecules involved in several important structural and mechanistic processes. Lipids are found in cellular membranes, give posture and stability to the cell, are actively participating in cellular signaling, and act as mediators in several important biological pathways. LÄS MER

  3. 22. Novel markers for smooth muscle cell modulation in vascular injury and disease

    Författare :Urszula Rykaczewska; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Smooth muscle cells (SMCs) are major constituents of the vascular wall, indispensable for basic physiological functions of a healthy vessel, such as regulating vascular tone and blood pressure, but also critical during disease development. With remarkable plasticity, SMCs act as early responders to vessel wall injury, where by activating molecular mechanisms, including phenotypic modulation and transdifferentiation, they counteract detrimental stimuli and aim to restore vascular homeostasis. LÄS MER

  4. 23. Fighting cardiometabolic disease : validation of new experimental models and therapeutic targets

    Författare :Mirko Enea Minniti; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The prevalence of cardiometabolic diseases (CMD) such as atherosclerotic cardiovascular diseases, type 2 diabetes mellitus and nonalcoholic fatty liver disease (NAFLD), has grown dramatically during the last decades. Hence, massive research efforts are allocated to identify the pathophysiological mechanisms and new therapeutic targets for these morbidities. LÄS MER

  5. 24. Metabolic risk markers and relative survival in patients with aortic stenosis requiring surgery

    Författare :Anders Holmgren; Ulf Näslund; Stefan Söderberg; Michael Henein; Rune Haaverstad; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; aortic stenosis; aortic valve surgery; coronary artery disease; prospective cohort study; risk markers; lipoprotein a ; apolipoproteins; proteomics; troponin T; C-reactive protein; relative survival; observed survival; kardiologi; Cardiology;

    Sammanfattning : Background: Aortic stenosis (AS) is the most common valve disorder requiring surgery in developed countries. The etiology of AS is only partly known.  Identification of new biomarkers in prospective studies could lead to novel insights in the etiology of AS, and possibly lead to improved clinical management. LÄS MER

  7. 25. The role of proprotein convertases in vascular disease

    Författare :Bianca E Suur; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : To date, the role of the proprotein convertase subtilisin/kexin (PCSK) family in vascular disease is largely unknown, with the exception of PCSK9 and its key function in lipid metabolism. The PCSK family constitutes of 9 different proteases, of which the first 7 show remarkable structural and functional overlap. LÄS MER