Sökning: "substituted 1"

Visar resultat 1 - 5 av 400 avhandlingar innehållade orden substituted 1.

  1. 1. Novel Rearrangements of Vinylaziridines: Aza-[2,3]-Wittig Rearrangements and [1,5]-Hydrogen Shifts

    Detta är en avhandling från Organic Chemistry, Lund University

    Författare :Jens Åhman; [1996]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; 6-tetrahydropyridines; 3; 2; substituted 1; indolizidine alkaloid synthesis; 5]-hydrogen shift; homodienyl-[1; 3]-Wittig rearrangement; vinylaziridine synthesis; aza-[2; N-alkylation of aziridines; allylic imines; 1-pyrrolines.; Organic chemistry; Organisk kemi;

    Sammanfattning : A route from epoxy alcohols to cis- and trans-trisubstituted vinylaziridines has been developed. The vinylaziridines have been used as substrates in the base induced aza-[2,3]-Wittig rearrangement to substituted 1,2,3,6-tetrahydropyridines. LÄS MER

  2. 2. On the Ring-Opening Reaction of Thiophene-1,1-dioxides and the Intramolecular Diels-Alder Reaction of Azanona- and AzadecatrienesI

    Detta är en avhandling från Organic Chemistry, Lund University

    Författare :Anders Sebastian Tsirk; [1997]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; transition states; 3-21G * ; intramolecular Diels-Alder reactions; asymmetric induction; multivariate optimization; kinetic isotope effects; rearrangements; secondary amines; 1-dioxides; Ring-opening reaction; thiophene-1; stereoselectivity.; Organic chemistry; Organisk kemi;

    Sammanfattning : Substituted thiophene-1,1-dioxides were synthesized and their ring-opening reactions with omega-unsaturated secondary amines were investigated; this led to a synthetic route to azatrienes and to the preparation of some polyhydroisoindoles and polyhydroisoquinolines via an intramolecular Diels-Alder reaction. By using 2-substituted pyrrolidines and piperidines various tetrahydrobenzo[f]indolizidines, benzo[b]quinolizidines, tetrahydrobenzo[a]indolizidines and tetrahydro[a]pyrrolizidines could be synthesized via the ring-opening of 3-bromo-2,5-dimmethylthiophene-1,1-dioxide and a subsequent intramolecular Diels-Alder reaction. LÄS MER

  3. 3. Lignin Model Compounds: Synthesis, Stereochemistry and Acidolysis

    Detta är en avhandling från Organic Chemistry, Lund University

    Författare :Shiming Li; [1998]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; boric acid complexes; Arylglycerol b-aryl ethers; stereochemistry; 3-Diaryl-2-propen-1-ols; 1; Phenylcoumarans; lignin model compounds; acidolysis; ion-exchange chromatography; 3-propanediols; 2-Diaryl-1; 2; X-ray crystallography;

    Sammanfattning : Lignin model compounds representative of structural elements in lignin of the b-1, b-5, b-O-4, cinnamaldehyde and cinnamyl alcohol types were synthesized. erythro-Forms of b-1 models of the 1,2-diaryl-1,3-propanediol type were prepared by BF3-catalyzed rearrangement of chalcone epoxides and subsequent reduction of the rearrangement products with NaBH4. LÄS MER

  4. 4. Structure-Assisted Design of Drugs Towards HIV-1 and Malaria Targets Applied on Reverse Transcriptase and Protease from HIV-1 and Plasmepsin II from Plasmodium falciparum

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Jimmy Lindberg; Uppsala universitet.; [2004]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; X-ray crystallography; Drug design; HIV-1; Malaria; Molekylärbiologi; NATURAL SCIENCES Biology Cell and molecular biology Molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi Molekylärbiologi;

    Sammanfattning : Globally of today, acquired immunodeficiency syndrome (AIDS) and malaria are two of the most threatening diseases known to mankind. The World Health Organization estimated that AIDS and malaria together claimed nearly 4 million lives in 2003 and many more were infected by the causative agent human immunodeficiency virus (HIV) and the Plasmodium falciparum (P. LÄS MER

  5. 5. New Methods for the Synthesis of 3-Substituted 1-Indanones A Palladium-Catalyzed Approach

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Anna Arefalk; Anders Hallberg; Mats Larhed; Juan Carlos Carretero; [2005]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Heck; palladium; indanone; annulation; microwave heating; triflate; sulfinyl imine; HIV-1 protease inhibitor; Organisk kemi; NATURAL SCIENCES Chemistry Organic chemistry; NATURVETENSKAP Kemi Organisk kemi;

    Sammanfattning : In medicinal chemistry, there is a constant need for new preparative methods, both to make the synthesis process more effective, and to increase the accessibility to a wide variety of compounds. A number of different approaches can be used to attain these goals. LÄS MER