Sökning: "subendothelial"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet subendothelial.

  1. 1. Leukocyte-endothelial interactions in arteries in vivo : a new concept in the study of physiology and disease in large blood vessels

    Författare :Einar Eriksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Atherosclerosis; leukocyte; cell adhesion molecule; chemokine; shear rate; capture; rolling; adhesion; subendothelial; cytokine; artery; intravital; in vivo;

    Sammanfattning : Pathophysiological events in large blood vessels contribute to immense morbidity and mortality in our society. A major clinical problem is a disease known as atherosclerosis. It involves a slow inflammatory deposition of lipid within the walls of large arteries that with time will weaken the arterial wall. LÄS MER

  3. 2. Atherogenic lipoproteins and their interaction with proteoglycans

    Författare :Christofer Flood; Göteborgs universitet; []
    Nyckelord :apolipoprotein B; atherosclerosis; LDL; proteoglycan; sPLA2; ; retention;

    Sammanfattning : Atherosclerosis is a multi-factorial disease and its pathogenesis is still unclear. However, accumulating evidence during recent years has led to the concept that subendothelial retention of atherogenic lipoproteins is the initiating event in atherogenesis. LÄS MER

  4. 3. Action and interaction of growth factors and regulatory molecules in vascular cells : With special reference to the IGF-I-system

    Författare :Gunilla Dahlfors; Anna Hultgårdh-Nilsson; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Vascular function is greatly influenced by growth factors and regulatory molecules that can interact with each other in a complex pattern in the vascular wall. In this thesis we studied how different substances of special interest in the pathogenesis of vascular disease interact and regulate each other's expressions in endothelial cells and vascular smooth muscle cells (VSMCs). LÄS MER

  5. 4. Platelet-lymphocyte cross-talk in atherogenesis : experimental studies on platelet-regulated lymphocyte adhesion and CD4+ T cell activation

    Författare :Zhu Linjing; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Atherosclerosis is an inflammatory and thrombotic disease. Platelets and lymphocytes, especially CD4+ T cells, are indispensable players during the initiation and progression of atherosclerotic lesion formation. During the early stage of atherogenesis, lymphocytes are generally thought to be recruited from arterial blood flow. LÄS MER

  7. 5. T-cell specificity and regulation in atherosclerosis

    Författare :Anton Gisterå; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cardiovascular disease is the main cause of death in the world. The underlying cause in most cases is atherosclerosis, a chronic inflammatory disease. Subendothelial retention of lipoproteins triggers monocyte-derived macrophages and T-helper (Th) 1 cells to form lipid-laden atherosclerotic plaques in the artery wall. LÄS MER